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https://hdl.handle.net/10356/101252
Title: | Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo | Authors: | Rice, Scott A. Kumar, Naresh Ho, Kitty Ka Kit Cole, Nerida Chen, Renxun Willcox, Mark D. P. |
Issue Date: | 2012 | Source: | Ho, K. K. K., Cole, N., Chen, R., Willcox, M. D. P., Rice, S. A., & Kumar, N. (2012). Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo. Antimicrobial Agents and Chemotherapy, 56(2), 1138-1141. | Series/Report no.: | Antimicrobial agents and chemotherapy | Abstract: | Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications. | URI: | https://hdl.handle.net/10356/101252 http://hdl.handle.net/10220/10995 |
ISSN: | 0066-4804 | DOI: | 10.1128/AAC.05814-11 | Rights: | © 2012 American Society for Microbiology. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SCELSE Journal Articles |
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