Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/98414
Title: HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer
Authors: Koh, Elisa
Pang, Cindy
Soh, Lay-Tin
Wang, Jin
Ho, Tew-Hong
Tay, Sun-Kuie
Lim-Tan, Soo-Kim
Lim, Kiat-Hon
Chia, John Whay-Kuang
Goh, Liang-Kee
Chay, Wen-Yee
Chew, Sung-Hock
Ong, Whee-Sze
Busmanis, Inny
Li, Xinyun
Thung, Sharyl
Ngo, Lynette
Lim, Sheow-Lei
Lim, Yong-Kuei
Chia, Yin-Nin
Keywords: Biological Sciences
Issue Date: 2013
Source: Chay, W. Y., Chew, S. H., Ong, W. S., Busmanis, I., Li, X., Thung, S., et al. (2013). HER2 Amplification and Clinicopathological Characteristics in a Large Asian Cohort of Rare Mucinous Ovarian Cancer. PLoS ONE, 8(4), e61565.
Series/Report no.: PLoS ONE
Abstract: Mucinous epithelial ovarian cancer has a poor prognosis in the advanced stages and responds poorly to conventional chemotherapy. We aim to elucidate the clinicopathological factors and incidence of HER2 expression of this cancer in a large Asian retrospective cohort from Singapore. Of a total of 133 cases, the median age at diagnosis was 48.3 years (range, 15.8–89.0 years), comparatively younger than western cohorts. Most were Chinese (71%), followed by Malays (16%), others (9.0%), and Indians (5%). 24% were noted to have a significant family history of malignancy of which breast and gastrointestinal cancers the most prominent. Majority of the patients (80%) had stage I disease at diagnosis. Information on HER2 status was available in 113 cases (85%). Of these, 31 cases (27.4%) were HER2+, higher than 18.8% reported in western population. HER2 positivity appeared to be lower among Chinese and higher among Malays patients (p = 0.052). With the current standard of care, there was no discernible impact of HER2 status on overall survival. (HR = 1.79; 95% CI, 0.66–4.85; p = 0.249). On the other hand, positive family history of cancer, presence of lymphovascular invasion, and ovarian surface involvements were significantly associated with inferior overall survival on univariate and continued to be statistically significant after adjustment for stage. While these clinical factors identify high risk patients, it is promising that the finding of a high incidence of HER2 in our Asian population may allow development of a HER2 targeted therapy to improve the management of mucinous ovarian cancers.
URI: https://hdl.handle.net/10356/98414
http://hdl.handle.net/10220/18445
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0061565
Schools: School of Biological Sciences 
Rights: © 2013 The Authors. This paper was published in PLoS ONE and is made available as an electronic reprint (preprint) with permission of the authors. The paper can be found at the following official DOI: [http://dx.doi.org/10.1371/journal.pone.0061565]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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