Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/104133
Title: Individual subject meta-analysis of parameters for Giardia duodenalis shedding in animal experimental models
Authors: Adell, A. D.
Miller, W. A.
Harvey, D. J.
Van Wormer, E.
Wuertz, S.
Conrad, P. A.
Keywords: DRNTU::Science::Medicine::Biomedical engineering
Issue Date: 2014
Source: Adell, A. D., Miller, W. A., Harvey, D. J., Van Wormer, E., Wuertz, S., & Conrad, P. A. (2014). Individual Subject Meta-Analysis of Parameters for Giardia duodenalis Shedding in Animal Experimental Models. BioMed Research International, 2014, 476142-.
Series/Report no.: BioMed research international
Abstract: Giardia duodenalis is a zoonotic protozoan parasite with public health importance worldwide. While articles about animal model infectivity have been published for G. duodenalis, the studies have used diverse protocols and parameters to evaluate the infectivity of this protozoan parasite. Hence, the objectives of this study were to (1) conduct a meta-analysis of published literature for cyst shedding and diarrhea outcomes in animal models and (2) develop recommendations to help standardize experimental dose response studies. Results showed that, for the outcome of cyst shedding in faeces, the covariates of infective stage (cyst versus trophozoite), Giardia dose, and the interactions between doses and infective stage, as well as dose and species of experimental host, were all significant ( value ≤ 0.05). This study suggests inoculation of the experimental host with cysts rather than trophozoites and administration of higher doses of Giardia will most likely result in cyst shedding. Based on the results of this meta-analysis, the infective stage (cyst versus trophozoite), parasite dose, and the interactions between dose and infective stage, as well as dose and species of experimental host, should be considered when designing experimental dose response studies that will assist in the study of zoonotic neglected tropical diseases globally.
URI: https://hdl.handle.net/10356/104133
http://hdl.handle.net/10220/19558
ISSN: 2314-6133
DOI: 10.1155/2014/476142
Schools: School of Civil and Environmental Engineering 
School of Biological Sciences 
Research Centres: Singapore Centre for Environmental Life Sciences Engineering 
Rights: © 2014 A. D. Adell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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