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https://hdl.handle.net/10356/104158
Title: | Chitosan microsphere scaffold tethered with RGD-conjugated poly(methacrylic acid) brushes as effective carriers for the endothelial cells | Authors: | Pehkonen, Simo O. Yang, Zhenyi Yuan, Shaojun Liang, Bin Liu, Yang Choong, Cleo Swee Neo |
Keywords: | DRNTU::Science::Medicine::Tissue engineering | Issue Date: | 2014 | Source: | Yang, Z., Yuan, S., Liang, B., Liu, Y., Choong, C., & Pehkonen, S. O. (2014). Chitosan Microsphere Scaffold Tethered with RGD-Conjugated Poly(methacrylic acid) Brushes as Effective Carriers for the Endothelial Cells. Macromolecular Bioscience, in press. | Series/Report no.: | Macromolecular bioscience | Abstract: | Endothelial cell–matrix interactions play a vital role in promoting vascularization of engineered tissues. The current study reports a facile and controllable method to develop a RGD peptide-functionalized chitosan microsphere scaffolds for rapid cell expansion of human umbilical vein endothelial cells (HUVECs). Functional poly(methacrylic acid) (PMAA) brushes are grafted from the chitosan microsphere surfaces via surface-initiated ATRP. Subsequent conjugation of RGD peptides on the pendent carboxyl groups of PMAA side chain is accomplished by carbodiimide chemistry to facilitate biocompatibility of the 3D CS scaffolding system. In vitro cell-loading assay of HUVECs exhibits a significant improvment of cell adhesion, spreading, and proliferation on the RGD peptide-immobilized CS microsphere surfaces. | URI: | https://hdl.handle.net/10356/104158 http://hdl.handle.net/10220/19856 |
ISSN: | 1616-5187 | DOI: | 10.1002/mabi.201400136 | Schools: | School of Materials Science & Engineering | Rights: | © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | MSE Journal Articles |
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