Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/106989
Title: Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice
Authors: Loke, Mun Fai
Vadivelu, Jamuna
Tan, Tuan Lin
Wong, Whye Yen
Khosravi, Yalda
Seow, Shih Wee
Amoyo, Arlaine Anne
Chiow, Kher Hsin
Poh, Qian Hui
Sentosa, Ignatius Mario Doli
Bunte, Ralph M.
Pettersson, Sven
Keywords: DRNTU::Science::Biological sciences::Human anatomy and physiology
Issue Date: 2015
Source: Khosravi, Y., Seow, S. W., Amoyo, A. A., Chiow, K. H., Tan, T. L., Wong, W. Y., et al.. (2015). Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice. Scientific reports, 5.
Series/Report no.: Scientific reports
Abstract: Helicobacter pylori, is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori. Despite H. pylori-infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional side effects of H. pylori are highly warranted.
URI: https://hdl.handle.net/10356/106989
http://hdl.handle.net/10220/25248
ISSN: 2045-2322
DOI: 10.1038/srep08731
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Singapore Centre for Environmental Life Sciences Engineering
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCELSE Journal Articles

SCOPUSTM   
Citations 10

34
Updated on Mar 18, 2024

Web of ScienceTM
Citations 10

29
Updated on Oct 30, 2023

Page view(s) 5

970
Updated on Mar 18, 2024

Download(s) 20

325
Updated on Mar 18, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.