Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/105225
Title: | Conjugated polymer nanodots as ultrastable long-term trackers to understand mesenchymal stem cell therapy in skin regeneration | Authors: | Li, Kai Jin, Guorui Mao, Duo Cai, Pingqiang Liu, Rongrong Tomczak, Nikodem Liu, Jie Chen, Xiaodong Kong, Deling Ding, Dan Liu, Bin |
Keywords: | DRNTU::Engineering::Materials::Functional materials | Issue Date: | 2015 | Source: | Jin, G., Mao, D., Cai, P., Liu, R., Tomczak, N., Liu, J., et al. (2015). Conjugated polymer nanodots as ultrastable long-term trackers to understand mesenchymal stem cell therapy in skin regeneration. Advanced functional materials, 25(27), 4263-4273. | Series/Report no.: | Advanced functional materials | Abstract: | Stem cell–based therapies hold great promise in providing desirable solutions for diseases that cannot be effectively cured by conventional therapies. To maximize the therapeutic potentials, advanced cell tracking probes are essential to understand the fate of transplanted stem cells without impairing their properties. Herein, conjugated polymer (CP) nanodots are introduced as noninvasive fluorescent trackers with high brightness and low cytotoxicity for tracking of mesenchymal stem cells (MSCs) to reveal their in vivo behaviors. As compared to the most widely used commercial quantum dot tracker, CP nanodots show significantly better long-term tracking ability without compromising the features of MSCs in terms of proliferation, migration, differentiation, and secretome. Fluorescence imaging of tissue sections from full-thickness skin wound–bearing mice transplanted with CP nanodot-labeled MSCs suggests that paracrine signaling of the MSCs residing in the regenerated dermis is the predominant contribution to promote skin regeneration, accompanied with a small fraction of endothelial differentiation. The promising results indicate that CP nanodots could be used as next generation of fluorescent trackers to reveal the currently ambiguous mechanisms in stem cell therapies through a facile and effective approach. | URI: | https://hdl.handle.net/10356/105225 http://hdl.handle.net/10220/25967 |
ISSN: | 1616-301X | DOI: | 10.1002/adfm.201501081 | Schools: | School of Materials Science & Engineering | Rights: | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | MSE Journal Articles |
SCOPUSTM
Citations
10
50
Updated on Mar 27, 2024
Web of ScienceTM
Citations
10
48
Updated on Oct 29, 2023
Page view(s) 50
503
Updated on Mar 27, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.