Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/96686
Title: | Asymmetric conjugate addition of grignard reagents to 3-silyl unsaturated esters for the facile preparation of enantioenriched β-silylcarbonyl compounds and allylic silanes | Authors: | Zhao, Kai Loh, Teck-Peng |
Keywords: | DRNTU::Science::Chemistry::Organic chemistry | Issue Date: | 2014 | Source: | Zhao, K., & Loh, T.-P. (2014). Asymmetric conjugate addition of grignard reagents to 3-silyl unsaturated esters for the facile preparation of enantioenriched β-silylcarbonyl compounds and allylic silanes. Chemistry - A European Journal, 20(50), 16764-16772. | Series/Report no.: | Chemistry - A European Journal | Abstract: | A highly enantioselective conjugate addition of Grignard reagents to 3-silyl unsaturated esters to deliver synthetically useful chiral β-silylcarbonyl compounds was developed. The synthetic value of this methodology was further illustrated by the synthesis of enantioenriched β-hydroxyl esters and the facile access granted to various α-chiral allylic silanes. A plethora of diastereoselective transformations of β-silylenolates were also investigated and afforded manifold organosilanes that contained contiguous stereogenic centers with excellent enantioselectivity. | URI: | https://hdl.handle.net/10356/96686 http://hdl.handle.net/10220/38502 |
ISSN: | 0947-6539 | DOI: | 10.1002/chem.201403849 | Schools: | School of Physical and Mathematical Sciences | Rights: | © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SPMS Journal Articles |
SCOPUSTM
Citations
20
22
Updated on Mar 22, 2024
Web of ScienceTM
Citations
20
21
Updated on Oct 28, 2023
Page view(s) 50
482
Updated on Mar 28, 2024
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.