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ABC transporters, neural stem cells and neurogenesis : a different perspective

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ABC transporters, neural stem cells and neurogenesis : a different perspective

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dc.contributor.author Lin, Tingting
dc.contributor.author Omedul Islam
dc.contributor.author Heese, Klaus
dc.date.accessioned 2010-03-03T02:51:05Z
dc.date.available 2010-03-03T02:51:05Z
dc.date.copyright 2006
dc.date.issued 2010-03-03T02:51:05Z
dc.identifier.citation Lin, T., Omedul, I., & Heese, K., (2006). ABC transporters, neural stem cells and neurogenesis: a different perspective. Cell Research, (16), 857-871.
dc.identifier.issn 1001-0602
dc.identifier.uri http://hdl.handle.net/10220/6199
dc.description.abstract Stem cells intrigue. They have the ability to divide exponentially, recreate the stem cell compartment, as well as create differentiated cells to generate tissues. Therefore, they should be natural candidates to provide a renewable source of cells for transplantation applied in regenerative medicine. Stem cells have the capacity to generate specific tissues or even whole organs like the blood, heart, or bones. A subgroup of stem cells, the neural stem cells (NSCs), is characterized as a self-renewing population that generates neurons and glia of the developing brain. They can be isolated, genetically manipulated and differentiated in vitro and reintroduced into a developing, adult or a pathologically altered central nervous system. NSCs have been considered for use in cell replacement therapies in various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Characterization of genes with tightly controlled expression patterns during differentiation represents an approach to understanding the regulation of stem cell commitment. The regulation of stem cell biology by the ATP-binding cassette (ABC) transporters has emerged as an important new field of investigation. As a major focus of stem cell research is in the manipulation of cells to enable differentiation into a targeted cell population; in this review, we discuss recent literatures on ABC transporters and stem cells, and propose an integrated view on the role of the ABC transporters, especially ABCA2, ABCA3, ABCB1 and ABCG2, in NSCs' proliferation, differentiation and regulation, along with comparisons to that in hematopoietic and other stem cells.
dc.format.extent 24 p.
dc.language.iso en
dc.relation.ispartofseries Cell research
dc.rights This is the author created version of a work that has been peer reviewed and accepted for publication by Cell Research, Nature Publishing Group. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1038/sj.cr.7310107].
dc.subject DRNTU::Science::Biological sciences::Molecular biology
dc.title ABC transporters, neural stem cells and neurogenesis : a different perspective
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1038/sj.cr.7310107
dc.description.version Accepted version

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