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Interleukin-6 and neural stem cells : more than gliogenesis

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Interleukin-6 and neural stem cells : more than gliogenesis

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Title: Interleukin-6 and neural stem cells : more than gliogenesis
Author: Omedul Islam; Gong, Xian Di; Rose-John, Stefan; Heese, Klaus
Copyright year: 2009
Abstract: Besides its wide range of action as a proinflammatory cytokine in the immune system, interleukin-6 (IL-6) has also attracted much attention due to its influence on the nervous system. In the present study we show that the designer fusion protein H-IL-6, consisting of IL-6 and its specific receptor IL-6R-α, but not IL-6 alone, mediates both neuro- as well as gliogenesis. Using immunocytochemistry, Western blot, and patch-clamp recording, we demonstrate that H-IL-6 induces the differentiation of neural stem cells (NSCs) specifically into glutamate-responsive neurons and two morphological distinctive astroglia cell types. H-IL-6–activated neurogenesis seems to be induced by the MAPK/CREB (mitogenactivated protein kinase/cAMP response element-binding protein) cascade, whereas gliogenesis is mediated via the STAT-3 (signal transducers and activators of transcription protein-3) signaling pathway. Our finding that IL-6 mediates both processes depending on its specific soluble receptor sIL-6R-α has implications for the potential treatment of neurodegenerative diseases.
Subject: DRNTU::Science::Biological sciences::Microbiology::Immunology
Type: Journal Article
Series/ Journal Title: Molecular biology of the cell
School: School of Biological Sciences
Rights: This paper was published by Molecular biology of the cell, American Society for Cell Biology. The officially published version can be found at the following URL: [http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E08-05-0463]. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
Version: Published version

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