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Interleukin-6 and neural stem cells : more than gliogenesis

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Interleukin-6 and neural stem cells : more than gliogenesis

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dc.contributor.author Omedul Islam
dc.contributor.author Gong, Xian Di
dc.contributor.author Rose-John, Stefan
dc.contributor.author Heese, Klaus
dc.date.accessioned 2010-03-03T03:12:49Z
dc.date.available 2010-03-03T03:12:49Z
dc.date.copyright 2009
dc.date.issued 2010-03-03T03:12:49Z
dc.identifier.citation Omedul I., Gong, X., Rose-John, S., & Heese, K. (2009). Interleukin-6 and Neural Stem Cells: more than Gliogenesis. Molecular Biology of the Cell, 20, 188-199.
dc.identifier.issn 1059-1524
dc.identifier.uri http://hdl.handle.net/10220/6200
dc.description.abstract Besides its wide range of action as a proinflammatory cytokine in the immune system, interleukin-6 (IL-6) has also attracted much attention due to its influence on the nervous system. In the present study we show that the designer fusion protein H-IL-6, consisting of IL-6 and its specific receptor IL-6R-α, but not IL-6 alone, mediates both neuro- as well as gliogenesis. Using immunocytochemistry, Western blot, and patch-clamp recording, we demonstrate that H-IL-6 induces the differentiation of neural stem cells (NSCs) specifically into glutamate-responsive neurons and two morphological distinctive astroglia cell types. H-IL-6–activated neurogenesis seems to be induced by the MAPK/CREB (mitogenactivated protein kinase/cAMP response element-binding protein) cascade, whereas gliogenesis is mediated via the STAT-3 (signal transducers and activators of transcription protein-3) signaling pathway. Our finding that IL-6 mediates both processes depending on its specific soluble receptor sIL-6R-α has implications for the potential treatment of neurodegenerative diseases.
dc.format.extent 12 p.
dc.language.iso en
dc.relation.ispartofseries Molecular biology of the cell
dc.rights This paper was published by Molecular biology of the cell, American Society for Cell Biology. The officially published version can be found at the following URL: [http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E08-05-0463]. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
dc.subject DRNTU::Science::Biological sciences::Microbiology::Immunology
dc.title Interleukin-6 and neural stem cells : more than gliogenesis
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1091/mbc.E08-05-0463
dc.description.version Published version

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