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Neurotrophins : more than Neurotrophic

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Neurotrophins : more than Neurotrophic

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dc.contributor.author Shamini Ayyadhury
dc.contributor.author Heese, Klaus
dc.date.accessioned 2010-03-03T03:28:18Z
dc.date.available 2010-03-03T03:28:18Z
dc.date.copyright 2007
dc.date.issued 2010-03-03T03:28:18Z
dc.identifier.citation Shamini, A., & Heese, K. (2007). Neurotrophins: more than neurotrophic. Current Immunology Reviews, 3(3), 189-215.
dc.identifier.issn 1573-3955
dc.identifier.uri http://hdl.handle.net/10220/6201
dc.description.abstract The Nerve Growth Factor (NGF) is the prototypic member of the neurotrophin (NT) family, which plays an essential role in the development and functioning of the vertebrate nervous system. Although originally defined by their actions on neuronal survival and differentiation in the peripheral (PNS) and central nervous systems (CNS), accumulating data indicate the presence of extensive interactions between the NTs and the immune system. NTs are released normally during lymphocyte and leukocyte development by the bone marrow and the thymus and later by secondary lymph organs to maintain responsiveness of these circulating naïve and memory immune cells. Functional NT receptors have been detected on the cells of the immune system and increased levels of NGF protein are found during the acute phase of various diseases with a significant inflammatory component. Furthermore, in certain conditions such as allergic asthma, the released NTs exacerbate the severity of the inflammation and prolong the diseased state. However, in the CNS, if one can control homeostasis of the internal environment, then the natural response of the infiltrating immune cells to release these NTs can be used to intervene at key points in the disease progression. These wider functions are likely to be of concern in any attempted therapeutic use of NGF or related NTs.
dc.format.extent 54 p.
dc.language.iso en
dc.relation.ispartofseries Current immunology reviews
dc.rights This is the author created version of a work that has been peer reviewed and accepted for publication by Current Immunology Reviews, Bentham Science Publishers. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://www.ingentaconnect.com/content/ben/cir/2007/00000003/00000003/art00004].
dc.subject DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
dc.title Neurotrophins : more than Neurotrophic
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://www.ingentaconnect.com/content/ben/cir/2007/00000003/00000003/art00004
dc.description.version Accepted version

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