Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/93785
Title: The molecular mechanism of B cell activation by toll-like receptor protein RP-105
Authors: Mecklenbräuker, Ingrid
Su, I. Hsin
Texido, Gemma
Leitges, Michael
Carsetti, Rita
Rajewsky, Klaus
Miyake, Kensuke
Tarakhovsky, Alexander
Chan, Vivien W. F.
Lowell, Clifford A.
Keywords: DRNTU::Science::Biological sciences::Molecular biology
Issue Date: 1998
Source: Chan, V. W. F., Mecklenbräuker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., et al. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. Journal of experimental medicine, 188(1), 93-101.
Series/Report no.: Journal of experimental medicine
Abstract: The B cell–specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C b I/II (PKC bI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105–mediated signaling cascade in B cells. We also find that negative regulation of RP-105–mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor–mediated arrest of RP-105–mediated B cell proliferation.
URI: https://hdl.handle.net/10356/93785
http://hdl.handle.net/10220/6798
DOI: 10.1084/jem.188.1.93
Schools: School of Biological Sciences 
Rights: © 1998 Rockefeller University Press. This paper was published in Journal of Experimental Medicine and is made available as an electronic reprint (preprint) with permission of Rockefeller University Press. The paper can be found at: [DOI: http://dx.doi.org/10.1084/jem.188.1.93]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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