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The molecular mechanism of B cell activation by toll-like receptor protein RP-105.

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The molecular mechanism of B cell activation by toll-like receptor protein RP-105.

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dc.contributor.author Chan, Vivien W. F.
dc.contributor.author Mecklenbräuker, Ingrid.
dc.contributor.author Su, I. Hsin.
dc.contributor.author Texido, Gemma.
dc.contributor.author Leitges, Michael.
dc.contributor.author Carsetti, Rita.
dc.contributor.author Lowell, Clifford A.
dc.contributor.author Rajewsky, Klaus.
dc.contributor.author Miyake, Kensuke.
dc.contributor.author Tarakhovsky, Alexander.
dc.date.accessioned 2011-05-25T03:16:20Z
dc.date.available 2011-05-25T03:16:20Z
dc.date.copyright 1998
dc.date.issued 2011-05-25T03:16:20Z
dc.identifier.citation Chan, V. W. F., Mecklenbräuker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., et al. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. Journal of experimental medicine, 188(1), 93-101.
dc.identifier.uri http://hdl.handle.net/10220/6798
dc.description.abstract The B cell–specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C b I/II (PKC bI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105–mediated signaling cascade in B cells. We also find that negative regulation of RP-105–mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor–mediated arrest of RP-105–mediated B cell proliferation.
dc.language.iso en
dc.relation.ispartofseries Journal of experimental medicine
dc.rights © 1998 Rockefeller University Press. This paper was published in Journal of Experimental Medicine and is made available as an electronic reprint (preprint) with permission of Rockefeller University Press. The paper can be found at: [DOI: http://dx.doi.org/10.1084/jem.188.1.93]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
dc.subject DRNTU::Science::Biological sciences::Molecular biology.
dc.title The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1084/jem.188.1.93
dc.description.version Published version

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