| dc.contributor.author |
Chan, Vivien W. F. |
| dc.contributor.author |
Mecklenbräuker, Ingrid. |
| dc.contributor.author |
Su, I. Hsin. |
| dc.contributor.author |
Texido, Gemma. |
| dc.contributor.author |
Leitges, Michael. |
| dc.contributor.author |
Carsetti, Rita. |
| dc.contributor.author |
Lowell, Clifford A. |
| dc.contributor.author |
Rajewsky, Klaus. |
| dc.contributor.author |
Miyake, Kensuke. |
| dc.contributor.author |
Tarakhovsky, Alexander. |
| dc.date.accessioned |
2011-05-25T03:16:20Z |
| dc.date.available |
2011-05-25T03:16:20Z |
| dc.date.copyright |
1998 |
| dc.date.issued |
2011-05-25T03:16:20Z |
| dc.identifier.citation |
Chan, V. W. F., Mecklenbräuker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., et al. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. Journal of experimental medicine, 188(1), 93-101. |
| dc.identifier.uri |
http://hdl.handle.net/10220/6798 |
| dc.description.abstract |
The B cell–specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like
proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate
that the Src-family protein tyrosine kinase Lyn, protein kinase C
b I/II (PKC
bI/II),
and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and
probably functionally connected elements of the RP-105–mediated signaling cascade in B cells.
We also find that negative regulation of RP-105–mediated activation of MAP kinases by membrane
immunoglobulin may account for the phenomenon of antigen receptor–mediated arrest
of RP-105–mediated B cell proliferation. |
| dc.language.iso |
en |
| dc.relation.ispartofseries |
Journal of experimental medicine |
| dc.rights |
© 1998 Rockefeller University Press. This paper was published in Journal of Experimental Medicine and is made available as an electronic reprint (preprint) with permission of Rockefeller University Press. The paper can be found at: [DOI: http://dx.doi.org/10.1084/jem.188.1.93]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. |
| dc.subject |
DRNTU::Science::Biological sciences::Molecular biology. |
| dc.title |
The molecular mechanism of B cell activation by toll-like receptor protein RP-105. |
| dc.type |
Journal Article |
| dc.contributor.school |
School of Biological Sciences |
| dc.identifier.doi |
http://dx.doi.org/10.1084/jem.188.1.93 |
| dc.description.version |
Published version |
