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Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method.

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Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method.

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Title: Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method.
Author: You, Chang Cheng.; Zhao, Yanli.; Liu, Yu.
Copyright year: 2001
Abstract: Spectrophotometric titrations were performed in aqueous buffer solution ( pH = 10. 5 , c =0. 025 mol/ L) at 25ᵒC determine the binding constant s of β-cyclodextrin (β-CD) , mono (6-O-α-malto-syl)- β-cyclodextrin (6-G2-β-CD) and mono [2-O-(2-hydroxypropyl)]-β-cyclodextrin (2-HP-β-CD) with several aliphatic chiral guest molecules using phenolphthalein as a spectral probe. The results obtained indicate that several weak interactions cooperatively contribute to the inclusion complexation of the β-cyclodextrin hosts and the complex stability is dominated by the size/shape-matching between host and guest. The substituent on the cyclodextrin derivatives changes it s original binding ability. For the relatively small guest molecules, i. e. , borneol , camphor and menthol , the molecular binding ability is 2-HP-β-CD > β-CD >6-G2-β-CD. Furthermore, the three β-cyclodextrin host s can also serve as chiral discrimination reagents and afford stronger binding ability toward ( + )-isomers. Among them, 2-HP-β-CD gives a moderate enantiometric selectivity of 1. 25 for ( + ) / ( - )-camphor.
Subject: DRNTU::Science::Biological sciences::Biochemistry.
Type: Journal Article
Series/ Journal Title: Chemical journal of Chinese universities
Rights: © 1995-2004 Tsinghua Tongfang Optical Disc Co., Ltd.
Version: Accepted version

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