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Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method

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Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method

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dc.contributor.author You, Chang Cheng
dc.contributor.author Zhao, Yanli
dc.contributor.author Liu, Yu
dc.date.accessioned 2011-09-05T07:09:34Z
dc.date.available 2011-09-05T07:09:34Z
dc.date.copyright 2001
dc.date.issued 2011-09-05
dc.identifier.citation You, C. C., Zhao, Y. L., & Liu, Y. (2001). Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method. Chemical journal of Chinese universities, 22(2), 218-222.
dc.identifier.issn 0251-0790
dc.identifier.uri http://hdl.handle.net/10220/6993
dc.description.abstract Spectrophotometric titrations were performed in aqueous buffer solution ( pH = 10. 5 , c =0. 025 mol/ L) at 25ᵒC determine the binding constant s of β-cyclodextrin (β-CD) , mono (6-O-α-malto-syl)- β-cyclodextrin (6-G2-β-CD) and mono [2-O-(2-hydroxypropyl)]-β-cyclodextrin (2-HP-β-CD) with several aliphatic chiral guest molecules using phenolphthalein as a spectral probe. The results obtained indicate that several weak interactions cooperatively contribute to the inclusion complexation of the β-cyclodextrin hosts and the complex stability is dominated by the size/shape-matching between host and guest. The substituent on the cyclodextrin derivatives changes it s original binding ability. For the relatively small guest molecules, i. e. , borneol , camphor and menthol , the molecular binding ability is 2-HP-β-CD > β-CD >6-G2-β-CD. Furthermore, the three β-cyclodextrin host s can also serve as chiral discrimination reagents and afford stronger binding ability toward ( + )-isomers. Among them, 2-HP-β-CD gives a moderate enantiometric selectivity of 1. 25 for ( + ) / ( - )-camphor.
dc.format.extent 5 p.
dc.language Chinese
dc.language.iso zh
dc.relation.ispartofseries Chemical journal of Chinese universities
dc.rights © 1995-2004 Tsinghua Tongfang Optical Disc Co., Ltd.
dc.subject DRNTU::Science::Biological sciences::Biochemistry.
dc.title Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method
dc.type Journal Article
dc.description.version Accepted version
dc.identifier.rims 159616

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