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Title: | Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method | Authors: | You, Chang Cheng Zhao, Yanli Liu, Yu |
Keywords: | DRNTU::Science::Biological sciences::Biochemistry | Issue Date: | 2001 | Source: | You, C. C., Zhao, Y. L., & Liu, Y. (2001). Molecular recognition study of β-cyclodextrin and its two derivatives with some aliphatic guests by competitive inclusion method. Chemical journal of Chinese universities, 22(2), 218-222. | Series/Report no.: | Chemical journal of Chinese universities | Abstract: | Spectrophotometric titrations were performed in aqueous buffer solution ( pH = 10. 5 , c =0. 025 mol/ L) at 25ᵒC determine the binding constant s of β-cyclodextrin (β-CD) , mono (6-O-α-malto-syl)- β-cyclodextrin (6-G2-β-CD) and mono [2-O-(2-hydroxypropyl)]-β-cyclodextrin (2-HP-β-CD) with several aliphatic chiral guest molecules using phenolphthalein as a spectral probe. The results obtained indicate that several weak interactions cooperatively contribute to the inclusion complexation of the β-cyclodextrin hosts and the complex stability is dominated by the size/shape-matching between host and guest. The substituent on the cyclodextrin derivatives changes it s original binding ability. For the relatively small guest molecules, i. e. , borneol , camphor and menthol , the molecular binding ability is 2-HP-β-CD > β-CD >6-G2-β-CD. Furthermore, the three β-cyclodextrin host s can also serve as chiral discrimination reagents and afford stronger binding ability toward ( + )-isomers. Among them, 2-HP-β-CD gives a moderate enantiometric selectivity of 1. 25 for ( + ) / ( - )-camphor. | URI: | https://hdl.handle.net/10356/92553 http://hdl.handle.net/10220/6993 |
ISSN: | 0251-0790 | Rights: | © 1995-2004 Tsinghua Tongfang Optical Disc Co., Ltd. | Fulltext Permission: | none | Fulltext Availability: | No Fulltext |
Appears in Collections: | SPMS Journal Articles |
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