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Title:
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Spectrophotometric study of fluorescence sensing and selective binding of biochemical substrates by 2,2'-bridged biso(β-cyclodextrin) and its water-soluble fullerene conjugate.
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Author:
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Liu, Yu.; Liang, Peng.; Chen, Yong.; Zhao, Yanli.; Ding, Fei.; Yu, Ao.
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Copyright year:
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2005 |
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Abstract:
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A bis(β-cyclodextrin)-fullerene conjugate (3) linked at the secondary hydroxyl side was prepared in a good
yield from its precursor N,N'-bis(2-(2-aminoethylamino)ethyl)malonamide-bridged bis(β-cyclodextrin) (2).
Spectrophotomeric studies on the conformation and the inclusion complexation behavior of 3 with a variety
of organic and biochemical substrates by means of UV-vis, FT-IR, NMR, fluorescence, and circular dichroism
spectroscopy showed that the bis(β-cyclodextrin)-fullerene conjugate displayed an intramolecular capsuletype
conformation in aqueous solution. Because of the multiple binding of bis(β-cyclodextrin) with substrates,
2 can act as an efficient fluorescence sensor for biochemical substrates, while its fullerene conjugate 3 displays
a capability of cleaving DNA under visible-light irradiation. |
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Subject:
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DRNTU::Science::Biological sciences::Biochemistry. |
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Type:
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Journal Article |
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Series/ Journal Title:
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Journal of physical Chemistry B |
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Rights:
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© 2005 American Chemical Society. |
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Version:
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None of the above |
