Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/93792
Title: Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
Authors: Nel, Andre E.
Zink, Jeffrey I.
Meng, Huan
Xue, Min
Xia, Tian
Zhao, Yanli
Tamanoi, Fuyuhiko
Stoddart, J. Fraser
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2010
Source: Meng, H., Xue, M., Xia, T., Zhao, Y. L., Tamanoi, F., Stoddart, J. F., & et al. (2010). Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves. Journal of the American Chemical Society, 132(36), 12690-12697.
Series/Report no.: Journal of the American chemical society
Abstract: Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of -cyclodextrin ( -CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB- 31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells.
URI: https://hdl.handle.net/10356/93792
http://hdl.handle.net/10220/7048
ISSN: 0002-7863
DOI: 10.1021/ja104501a
Schools: School of Physical and Mathematical Sciences 
Rights: © 2010 American Chemical Society
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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