mirage

Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.

DSpace/Manakin Repository

 

Search DR-NTU


Advanced Search Subject Search

Browse

My Account

Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.

Show simple item record

dc.contributor.author Meng, Huan.
dc.contributor.author Xue, Min.
dc.contributor.author Xia, Tian.
dc.contributor.author Zhao, Yanli.
dc.contributor.author Tamanoi, Fuyuhiko.
dc.contributor.author Stoddart, J. Fraser.
dc.contributor.author Zink, Jeffrey I.
dc.contributor.author Nel, Andre E.
dc.date.accessioned 2011-09-14T07:17:04Z
dc.date.available 2011-09-14T07:17:04Z
dc.date.copyright 2010
dc.date.issued 2011-09-14
dc.identifier.citation Meng, H., Xue, M., Xia, T., Zhao, Y. L., Tamanoi, F., Stoddart, J. F., & et al. (2010). Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves. Journal of the American Chemical Society, 132(36), 12690-12697.
dc.identifier.issn 0002-7863
dc.identifier.uri http://hdl.handle.net/10220/7048
dc.description.abstract Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of -cyclodextrin ( -CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB- 31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells.
dc.format.extent 8 p.
dc.language.iso en
dc.relation.ispartofseries Journal of the American chemical society
dc.rights © 2010 American Chemical Society
dc.subject DRNTU::Science::Biological sciences::Biochemistry.
dc.title Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.
dc.type Journal Article
dc.contributor.school School of Physical and Mathematical Sciences
dc.identifier.doi http://dx.doi.org/10.1021/ja104501a
dc.identifier.rims 159765

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Statistics

Total views

All Items Views
Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. 391

Total downloads

All Bitstreams Views
ja104501a.pdf 4

Top country downloads

Country Code Views
Singapore 3

Top city downloads

city Views
Singapore 3