Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/93793
Title: pH-operated nanopistons on the surfaces of mesoporous silica nanoparticles
Authors: Botros, Youssry Y.
Zink, Jeffrey I.
Zhao, Yanli
Li, Zongxi
Kabehie, Sanaz
Stoddart, J. Fraser
Keywords: DRNTU::Science::Biological sciences::Biochemistry
Issue Date: 2010
Source: Zhao, Y. L., Li, Z., Kabehie, S., Botros, Y. Y., Stoddart, J. F., & Zink, J. I. (2010). pH-Operated Nanopistons on the Surfaces of Mesoporous Silica Nanoparticles. Journal of the American Chemical Society, 132(37), 13016-13025.
Series/Report no.: Journal of the American chemical society
Abstract: The development of drug delivery systems for the targeted and on-demand release of pharmaceutical products has risen rapidly to become a contemporary challenge in the field of nanobiotechnology. Biocompatible mechanized phosphonate-clothed silica nanoparticles have been designed and fabricated in which the supramolecular machinery, which covers the surfaces of the nanoparticles, behaves like nanopistons, releasing encapsulated guest molecules in a controlled fashion under acidic conditions. The mechanized nanoparticles consist of a monolayer of -cyclodextrin ( -CD) rings positioned selectively around the orifices of the nanopores of the mesoporous nanoparticles. A rhodamine B/benzidine conjugate was prepared for use as the nanopistons for movement in and out of the cylindrical cavities provided by the -CD rings on the surfaces of the nanoparticles. Luminescence experiments indicated that the mechanized nanoparticles were able to store small cargo molecules (e.g., 2,6-naphthalenedisulfonic acid disodium) within their nanopores at neutral pH and then release them by passage through the cavities of the -CD rings as soon as the pH was lowered to ∼5. In further investigations, the phosphonate-covered silica nanoparticles were functionalized selectively with the -CD rings, but on this occasion, the seven linkers attaching the rings to the orifices surrounding the nanopores contained cleavable imine double bonds. The -CD rings on the surface of the nanoparticles served as gates for the storage of large cargo molecules (e.g., rhodamine B) inside the nanopores of the nanoparticles under neutral conditions. Since imine bonds can be hydrolyzed under acidic conditions, the -CD rings could be severed from the surface of the nanoparticles when the pH was decreased to 6, releasing the large cargo molecules. The results described here present a significant step toward the development of pH-responsive nanoparticle-based dual drug delivery vehicles that are potentially capable of being interfaced with biological systems.
URI: https://hdl.handle.net/10356/93793
http://hdl.handle.net/10220/7056
ISSN: 0002-7863
DOI: 10.1021/ja105371u
Schools: School of Physical and Mathematical Sciences 
Rights: © 2010 American Chemical Society
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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