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Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites

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Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites

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dc.contributor.author Gao, Xiaohong
dc.contributor.author Yeo, Kim Pin
dc.contributor.author Aw, Sharon Siqi
dc.contributor.author Kuss, Claudia
dc.contributor.author Iyer, Jayasree K.
dc.contributor.author Genesan, Saraswathy
dc.contributor.author Rajamanonmani, Ravikumar
dc.contributor.author Lescar, Julien
dc.contributor.author Bozdech, Zbynek
dc.contributor.author Preiser, Peter Rainer
dc.date.accessioned 2011-09-15T01:37:24Z
dc.date.available 2011-09-15T01:37:24Z
dc.date.copyright 2008
dc.date.issued 2011-09-15
dc.identifier.citation Gao, X., Yeo, K. P., Aw, S. S., Kuss, C., Iyer, J. K., Genesan, S. & et al. (2008) Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum Merozoites. PLoS Pathog, 4(7).
dc.identifier.issn 1553-7366
dc.identifier.uri http://hdl.handle.net/10220/7060
dc.description.abstract Invasion by the malaria merozoite depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and erythrocyte binding proteins/ligands (EBLs). The combination of different RBLs and EBLs expressed in a merozoite defines the invasion pathway utilized and could also play a role in parasite virulence. The binding regions of EBLs lie in a conserved cysteine-rich domain while the binding domain of RBL is still not well characterized. Here, we identify the erythrocyte binding region of the P. falciparum reticulocyte binding protein homologue 1 (PfRH1) and show that antibodies raised against the functional binding region efficiently inhibit invasion. In addition, we directly demonstrate that changes in the expression of RBLs can constitute an immune evasion mechanism of the malaria merozoite.
dc.format.extent 15 p.
dc.language.iso en
dc.relation.ispartofseries PLoS pathogens
dc.rights © 2008 Gao et al.
dc.subject DRNTU::Science::Biological sciences::Microbiology::Immunology
dc.title Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1371/journal.ppat.1000104
dc.description.version Published version
dc.identifier.rims 96210

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