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Title:
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On DNA modelling : interaction of a double helicoidal structure with viscous bio-fluid.
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Author:
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Lim, C. W.; Shu, Jian Jun.
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Copyright year:
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2001 |
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Abstract:
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The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluidstructure
interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watson-Crick DNA model subjected to viscous, low speed organic fluid loading is formulated. Numerical solutions based on the variational principle are presented for a
linearized flow field as examples. Significant dynamical responses such as deformation components and resultants are discussed. A proposal for matching of DNA sequential characteristics with respect to the nonlinear dynamical responses is outlined in order to reveal information regarding DNA sequencing by means of a fluid-structure dynamical approach. |
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Subject:
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DRNTU::Engineering::Mechanical engineering::Bio-mechatronics. |
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Type:
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Journal Article |
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Series/ Journal Title:
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Automedica |
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School:
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School of Mechanical and Aerospace Engineering |
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Related Organization:
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City University of Hong Kong |
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Rights:
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© 2001 OPA (Overseas Publishers Association) N.V. |
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Version:
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Accepted version |
