Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/94497
Title: Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum
Authors: Kuss, Claudia
Gan, Chee Sian
Gunalan, Karthigayan
Bozdech, Zbynek
Sze, Siu Kwan
Preiser, Peter Rainer
Keywords: DRNTU::Science::Biological sciences::Microbiology::Virology
Issue Date: 2011
Source: Kuss, C., Gan, C. S., Gunalan, K., Bozdech, Z., Sze, S. K., & Preiser, P. R. (2011). Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum. Molecular & cellular proteomics.
Series/Report no.: Molecular & cellular proteomics
Abstract: Differential expression of ligands in the human malaria parasite Plasmodium falciparum enables it to recognize different receptors on the erythrocyte surface thereby providing alternative invasion pathways. Switching of invasion from using sialated to non-sialated erythrocyte receptors have been linked to the transcriptional activation of a single parasite ligand. We have used quantitative proteomics to show that in addition to this single known change there are a significant number of changes in the expression of merozoite proteins that are regulated independent of transcription during invasion pathway switching. These results demonstrate a so far unrecognized mechanism by which the malaria parasite is able to adapt to variations in the host cell environment by posttranscriptional regulation.
URI: https://hdl.handle.net/10356/94497
http://hdl.handle.net/10220/7417
DOI: 10.1074/mcp.M111.010645
Schools: School of Biological Sciences 
Rights: Copyright © 2011, The American Society for Biochemistry and Molecular Biology http://www.mcponline.org/content/early/2011/10/24/mcp.M111.010645.short
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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