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Quantitative proteomics reveals new insights into erythrocyte invasion by plasmodium falciparum.

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Quantitative proteomics reveals new insights into erythrocyte invasion by plasmodium falciparum.

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dc.contributor.author Kuss, Claudia.
dc.contributor.author Gan, Chee Sian.
dc.contributor.author Gunalan, Karthigayan.
dc.contributor.author Bozdech, Zbynek.
dc.contributor.author Sze, Siu Kwan.
dc.contributor.author Preiser, Peter Rainer.
dc.date.accessioned 2011-12-16T06:29:34Z
dc.date.available 2011-12-16T06:29:34Z
dc.date.copyright 2011
dc.date.issued 2011-12-16
dc.identifier.citation Kuss, C., Gan, C. S., Gunalan, K., Bozdech, Z., Sze, S. K., & Preiser, P. R. (2011). Quantitative proteomics reveals new insights into erythrocyte invasion by plasmodium falciparum. Molecular & cellular proteomics.
dc.identifier.uri http://hdl.handle.net/10220/7417
dc.description.abstract Differential expression of ligands in the human malaria parasite Plasmodium falciparum enables it to recognize different receptors on the erythrocyte surface thereby providing alternative invasion pathways. Switching of invasion from using sialated to non-sialated erythrocyte receptors have been linked to the transcriptional activation of a single parasite ligand. We have used quantitative proteomics to show that in addition to this single known change there are a significant number of changes in the expression of merozoite proteins that are regulated independent of transcription during invasion pathway switching. These results demonstrate a so far unrecognized mechanism by which the malaria parasite is able to adapt to variations in the host cell environment by posttranscriptional regulation.
dc.language.iso en
dc.relation.ispartofseries Molecular & cellular proteomics
dc.rights Copyright © 2011, The American Society for Biochemistry and Molecular Biology http://www.mcponline.org/content/early/2011/10/24/mcp.M111.010645.short
dc.subject DRNTU::Science::Biological sciences::Microbiology::Virology.
dc.title Quantitative proteomics reveals new insights into erythrocyte invasion by plasmodium falciparum.
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi 10.1074/mcp.M111.010645
dc.description.version Accepted version

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