mirage

Design of β-hairpin peptides for modulation of cell adhesion by β-turn constraint.

DSpace/Manakin Repository

 

Search DR-NTU


Advanced Search Subject Search

Browse

My Account

Design of β-hairpin peptides for modulation of cell adhesion by β-turn constraint.

Show simple item record

dc.contributor.author Giddu, Sumana.
dc.contributor.author Subramanian, Vivekanandan.
dc.contributor.author Yoon, Ho Sup.
dc.contributor.author Satyanarayanajois, Seetharama D.
dc.date.accessioned 2012-01-26T01:34:47Z
dc.date.available 2012-01-26T01:34:47Z
dc.date.copyright 2009
dc.date.issued 2012-01-26
dc.identifier.citation Giddu, S., Subramanian, V., Yoon, H. S., & Satyanarayanajois, S. D. (2009). Design of β-Hairpin Peptides for Modulation of Cell Adhesion by β-Turn Constraint. Journal of Medicinal Chemistry, 52(3), 726-736.
dc.identifier.uri http://hdl.handle.net/10220/7477
dc.description.abstract The CD2−CD58 interaction in immune regulation and disease pathology has provided new targets for developing potential immunosuppressive agents. In the present study, we report the introduction of constraints to generate β-hairpin structures from the strand sequences of CD2 protein. The β-hairpin structures were induced in the designed peptides by introducing Pro-Gly sequences in the peptides. Results from NMR and MD simulation indicated that the peptides exhibited β-turn structure at the X-Pro-Gly-Y sequence and formed the β-hairpin structure in solution. The ability of these peptides to inhibit cell adhesion was evaluated by two cell adhesion assays. Among the peptides studied (1−4) (P1−P4), peptides 2−4 were able to inhibit cell adhesion between Jurkat cells and SRBC nearly 50% at 180 μM, and 80% inhibition between Jurkat cells and Caco-2 cells was seen at 90 μM. Peptide 1 did not show significant inhibition activity compared to control.
dc.language.iso en
dc.relation.ispartofseries Journal of medicinal Chemistry
dc.rights © 2009 American Chemical Society.
dc.subject DRNTU::Science::Biological sciences::Molecular biology.
dc.title Design of β-hairpin peptides for modulation of cell adhesion by β-turn constraint.
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1021/jm8008212

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record