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Labeling and tracking P2 purinergic receptors in living cells using ATP-conjugated quantum dots

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Labeling and tracking P2 purinergic receptors in living cells using ATP-conjugated quantum dots

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Title: Labeling and tracking P2 purinergic receptors in living cells using ATP-conjugated quantum dots
Author: Jiang, Shan; Liu, Aiping; Duan, Hongwei; Soo, Jianchow; Chen, Peng
Copyright year: 2011
Abstract: It has been increasingly recognized that adenosine-5 ′ -triphosphate (ATP) signaling through P2 purinergic receptors has a diverse infl uence on cell functions and human health. In this contribution, a simple and non-invasive method to specifi cally label P2 receptors using ATP-conjugated quantum dots (QDs) is demonstrated. In addition, the endocytosis, vesicular traffi cking, and recycling of QD-labeled P2 receptors are studied under different physiological conditions using confocal and total internal refl ection fl uorescence microscopy.
Subject: DRNTU::Engineering::Chemical engineering
Type: Journal Article
Series/ Journal Title: Advanced functional materials
School: School of Chemical and Biomedical Engineering
Rights: © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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