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Nanoelectronic detection of triggered secretion of pro-inflammatory cytokines using CMOS compatible silicon nanowires.

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Nanoelectronic detection of triggered secretion of pro-inflammatory cytokines using CMOS compatible silicon nanowires.

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dc.contributor.author Pui, Tze Sian.
dc.contributor.author Agarwal, Ajay.
dc.contributor.author Ye, Feng.
dc.contributor.author Huang, Yinxi.
dc.contributor.author Chen, Peng.
dc.date.accessioned 2012-02-02T05:41:39Z
dc.date.available 2012-02-02T05:41:39Z
dc.date.copyright 2010
dc.date.issued 2012-02-02
dc.identifier.citation Pui, T.-S., Agarwal, A., Ye, F., Huang, Y. & Chen, P. (2011) Nanoelectronic Detection of Triggered Secretion of Pro-inflammatory Cytokines Using CMOS Compatible Silicon Nanowires. Biosensors and Bioelectronics, 26(5), 2746-2750.
dc.identifier.issn 0956-5663
dc.identifier.uri http://hdl.handle.net/10220/7493
dc.description.abstract Nanotechnology, such as nanoelectronic biosensors, is bringing new opportunities and tools to the studies of cell biology, clinical applications, and drug discovery. In this study, cyrstalline silicon nanowire based field-effect transistors fabricated using top-down approach were employed to parallelly detect pro-inflammatory cytokines in the complex biological fluids (cell culture medium and blood samples) with high specificity and femtomolar sensitivity. Using this technique, the dynamic secretion of TNFalpha and IL6 was revealed during the immune response of macrophages and rats to the stimulation of bacteria endotoxin. This technique could provide a unique platform to examine the profile of complex immune responses for fundamental studies and diagnosis.
dc.format.extent 5 p.
dc.language.iso en
dc.relation.ispartofseries Biosensors & bioelectronics
dc.rights © 2010 Elsevier B.V.  This is the author created version of a work that has been peer reviewed and accepted for publication by Biosensors and Bioelectronics, Elsevier B.V.  It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at: [DOI: http://dx.doi.org/10.1016/j.bios.2010.09.059 ]
dc.subject DRNTU::Engineering::Chemical engineering.
dc.title Nanoelectronic detection of triggered secretion of pro-inflammatory cytokines using CMOS compatible silicon nanowires.
dc.type Journal Article
dc.contributor.school School of Chemical and Biomedical Engineering
dc.identifier.doi http://dx.doi.org/10.1016/j.bios.2010.09.059
dc.description.version Accepted version
dc.contributor.organization Institute of Microelectronics, A*STAR

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