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Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays

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Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays

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dc.contributor.author Ye, Feng
dc.contributor.author Than, Aung
dc.contributor.author Zhao, Yanying
dc.contributor.author Goh, Kian Hong
dc.contributor.author Chen, Peng
dc.date.accessioned 2012-02-06T02:56:18Z
dc.date.available 2012-02-06T02:56:18Z
dc.date.copyright 2010
dc.date.issued 2012-02-06
dc.identifier.citation Ye, F., Than, A., Zhao, Y., Goh, K. H. & Chen, P. (2010). Vesicular storage, vesicle trafficking, and secretion of leptin and resistin: the similarities, differences and interplays. Journal of Endocrinology, 206, 27–36.
dc.identifier.uri http://hdl.handle.net/10220/7502
dc.description.abstract Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In this work, we have comparatively studied several key aspects of leptin and resistin secretion from 3T3-L1 adipocytes. It was found that leptin and resistin molecules are compartmentalized into different secretory vesicles. The trafficking of leptin and resistin vesicles, and the secretion of leptin and resistin are oppositely regulated by insulin/glycolytic substrates and cAMP/protein kinase A. Interestingly, these two adipokines adversely influence each other on secretion and vesicle trafficking. Finally, we demonstrated that both leptin and resistin secretion are Ca2+ dependent.
dc.format.extent 35 p.
dc.language.iso en
dc.relation.ispartofseries Journal of endocrinology
dc.rights © 2010 Society for Endocrinology.  This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Endocrinology, Society for Endocrinology.  It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at: [DOI: http://dx.doi.org/10.1677/JOE-10-0090 ]
dc.subject DRNTU::Science::Medicine::Biomedical engineering
dc.title Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
dc.type Journal Article
dc.contributor.school School of Chemical and Biomedical Engineering
dc.identifier.doi http://dx.doi.org/10.1677/JOE-10-0090
dc.description.version Accepted version

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