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Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor

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Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor

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dc.contributor.author Zhou, Ming-Ming
dc.contributor.author Meadows, Robert P.
dc.contributor.author Logan, Timothy M.
dc.contributor.author Yoon, Ho Sup
dc.contributor.author Wade, Warren S.
dc.contributor.author Ravichandran, Kodimangalam S.
dc.contributor.author Burakoffe, Steven J.
dc.contributor.author Fesik, Stephen W.
dc.date.accessioned 2012-02-06T04:27:41Z
dc.date.available 2012-02-06T04:27:41Z
dc.date.copyright 1995
dc.date.issued 2012-02-06
dc.identifier.citation Zhou, M. M., Meadows, R. P., Logan, T. M., Yoon, H. S., Wade, W. S., Ravichandran, K. S., et al. (1995). Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor. Proceedings of the National Academy of Sciences, 92(17), 7784-7788.
dc.identifier.uri http://hdl.handle.net/10220/7506
dc.description.abstract Shc is a widely expressed adapter protein that plays an important role in signaling via a variety of cell surface receptors and has been implicated in coupling the stimulation of growth factor, cytokine, and antigen receptors to the Ras signaling pathway. She interacts with several tyrosine-phosphorylated receptors through its C-terminal SH2 domain, and one of the mechanisms of T-cell receptor-mediated Ras activation involves the interaction of the Shc SH2 domain with the tyrosine-phosphorylated zeta chain of the T-cell receptor. Here we describe a high-resolution NMR structure of the Shc SH2 domain complexed to a phosphopeptide (GHDGLpYQGLSTATK) corresponding to a portion of the zeta chain of the T-cell receptor. Although the overall architecture of the protein is similar to other SH2 domains, distinct structural differences were observed in the smaller beta-sheet, BG loop, (pY + 3) phosphopeptide-binding site, and relative position of the bound phosphopeptide.
dc.language.iso en
dc.rights © 1995 National Academy of Sciences. This is the author created version of a work that has been peer reviewed and accepted for publication by Proceedings of the National Academy of Sciences , National Academy of Sciences.  It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at: http://dx.doi.org/10.1073/pnas.92.17.7784
dc.subject DRNTU::Science::Biological sciences.
dc.title Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor
dc.type Conference Paper
dc.contributor.conference National Academy of Sciences (1995)
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1073/pnas.92.17.7784
dc.description.version Accepted version

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