mirage

The crosstalks between adipokines and catecholamines

DSpace/Manakin Repository

 

Search DR-NTU


Advanced Search Subject Search

Browse

My Account

The crosstalks between adipokines and catecholamines

Show simple item record

dc.contributor.author Than, Aung
dc.contributor.author Ye, Feng
dc.contributor.author Xue, Renhao
dc.contributor.author Ong, Jun Wei
dc.contributor.author Poh, Chueh Loo
dc.contributor.author Chen, Peng
dc.date.accessioned 2012-02-14T06:31:26Z
dc.date.available 2012-02-14T06:31:26Z
dc.date.copyright 2010
dc.date.issued 2012-02-14
dc.identifier.citation Than, A., Ye, F., Xue, R., Ong, J. W., Poh, C. L. & Chen P. (2011). The Crosstalks Between Adipokines and Catecholamines. Molecular and Cellular Endocrinology, 332(1-2), 261-270.
dc.identifier.uri http://hdl.handle.net/10220/7521
dc.description.abstract Adipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform. We demonstrate that all catecholamines inhibit vesicle trafficking and secretion of leptin and resistin through β-adrenergic receptors, while leptin and resistin enhance the vesicle trafficking and secretion of catecholamines through PKC, PKA, MAPK kinase and Ca2+ dependent pathways. The crosstalks between adipokines and catecholamines were further corroborated by co-culturing 3T3-L1 adipocytes and PC12 cells. Our findings highlight the importance of adipo-adrenal axis in energy metabolism and the intricate interactions between metabolic hormones.
dc.language.iso en
dc.relation.ispartofseries Molecular and cellular endocrinology
dc.rights © 2010 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Molecular and Cellular Endocrinology, Elsevier Ireland Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1016/j.mce.2010.11.002]
dc.subject DRNTU::Science::Medicine::Biomedical engineering
dc.title The crosstalks between adipokines and catecholamines
dc.type Journal Article
dc.contributor.school School of Chemical and Biomedical Engineering
dc.identifier.doi http://dx.doi.org/10.1016/j.mce.2010.11.002
dc.description.version Accepted version

Files in this item

Files Size Format View Description
The Crosstalks ... nes and Catecholamines.pdf 1.151Mb PDF View/Open Main article

This item appears in the following Collection(s)

Show simple item record

Statistics

Total views

All Items Views
The crosstalks between adipokines and catecholamines 392

Total downloads

All Bitstreams Views
The Crosstalks Between Adipokines and Catecholamines.pdf 221
AdipokineCatecholamines2010.pdf 12

Top country downloads

Country Code Views
United States of America 63
China 59
Singapore 29
Taiwan 20
Japan 8

Top city downloads

city Views
Mountain View 40
Beijing 33
Singapore 29
Taichung 10
Cambridge 2

Downloads / month

  2014-06 2014-07 2014-08 total
The Crosstalks Between Adipokines and Catecholamines.pdf 0 0 12 12