The crosstalks between adipokines and catecholamines

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The crosstalks between adipokines and catecholamines

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dc.contributor.author Than, Aung
dc.contributor.author Ye, Feng
dc.contributor.author Xue, Renhao
dc.contributor.author Ong, Jun Wei
dc.contributor.author Poh, Chueh Loo
dc.contributor.author Chen, Peng
dc.date.accessioned 2012-02-14T06:31:26Z
dc.date.available 2012-02-14T06:31:26Z
dc.date.copyright 2010
dc.date.issued 2012-02-14
dc.identifier.citation Than, A., Ye, F., Xue, R., Ong, J. W., Poh, C. L. & Chen P. (2011). The Crosstalks Between Adipokines and Catecholamines. Molecular and Cellular Endocrinology, 332(1-2), 261-270.
dc.identifier.uri http://hdl.handle.net/10220/7521
dc.description.abstract Adipocytes, which secrete a spectrum of adipokines, play an integral role in metabolism via communications with other endocrine cells. In the present work, we have studied the interplays between adipokines and catecholamines, using 3T3-L1 adipocytes and PC12 cells as the cell models and an integrative experimental platform. We demonstrate that all catecholamines inhibit vesicle trafficking and secretion of leptin and resistin through β-adrenergic receptors, while leptin and resistin enhance the vesicle trafficking and secretion of catecholamines through PKC, PKA, MAPK kinase and Ca2+ dependent pathways. The crosstalks between adipokines and catecholamines were further corroborated by co-culturing 3T3-L1 adipocytes and PC12 cells. Our findings highlight the importance of adipo-adrenal axis in energy metabolism and the intricate interactions between metabolic hormones.
dc.language.iso en
dc.relation.ispartofseries Molecular and cellular endocrinology
dc.rights © 2010 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Molecular and Cellular Endocrinology, Elsevier Ireland Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1016/j.mce.2010.11.002]
dc.subject DRNTU::Science::Medicine::Biomedical engineering
dc.title The crosstalks between adipokines and catecholamines
dc.type Journal Article
dc.contributor.school School of Chemical and Biomedical Engineering
dc.identifier.doi http://dx.doi.org/10.1016/j.mce.2010.11.002
dc.description.version Accepted version
dc.identifier.rims 163183

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