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Solution structure of a pleckstrin-homology domain

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Solution structure of a pleckstrin-homology domain

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Title: Solution structure of a pleckstrin-homology domain
Author: Yoon, Ho Sup; Hajduk, Philip J.; Petros, Andrew M.; Olejniczak, Edward T.; Meadows, Robert P.; Fesik, Stephen W.
Copyright year: 1994
Abstract: PLECKSTRIN1, the major protein kinase C substrate of platelets, contains domains of about 100 amino acids at the amino and carboxy termini that have been found in a number of proteins, including serine/threonine kinases, GTPase-activating proteins, phospholipases and cytoskeletal proteins2–5. These conserved sequences, termed pleckstrin-homology (PH) domains, are thought to be involved in signal transduction. But the details of the function and binding partners of the PH domains have not been characterized. Here we report the solution structure of the N-terminal pleckstrin-homology domain of pleckstrin determined using heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. The structure consists of an up-and-down β-barrel of seven antiparallel β-strands and a C-terminal amphiphilic α-helix that caps one end of the barrel. The overall topology of the domain is similar to that of the retinol-binding protein family of structures6–10.
Subject: DRNTU::Science::Biological sciences.
Type: Journal Article
Series/ Journal Title: Nature
School: School of Biological Sciences
Rights: © 1994 Nature Publishing Group. This is the author created version of a work that has been peer reviewed and accepted for publication by Nature, Nature Publishing Group. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at:http://dx.doi.org/10.1038/369672a0
Version: Accepted version

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