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An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching.

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An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching.

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Title: An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching.
Author: Kong, Tian Fook.; E, Huan Shin.; Sugiarto, Hendrik Santoso.; Liew, Hwi Fen.; Wang, Xinghua.; Lew, Wen Siang.; Nguyen, Nam-Trung.; Chen, Yong.
Copyright year: 2010
Abstract: The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz.
Subject: DRNTU::Engineering::Mechanical engineering.
Type: Journal Article
Series/ Journal Title: Microfluidics and nanofluidics
School: School of Mechanical and Aerospace Engineering
Rights: © 2010 Springer-Verlag. This is the author created version of a work that has been peer reviewed and accepted for publication by Microfluidics and nanofluidics, Springer-Verlag. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at:[DOI: http://dx.doi.org/10.1007/s10404-010-0735-8]

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