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Microfluidic on-chip fluorescence-activated interface control system

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Microfluidic on-chip fluorescence-activated interface control system

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dc.contributor.author Li, Haiwang
dc.contributor.author Nguyen, Nam-Trung
dc.contributor.author Wong, Teck Neng
dc.contributor.author Ng, S. L.
dc.date.accessioned 2012-04-12T04:39:41Z
dc.date.available 2012-04-12T04:39:41Z
dc.date.copyright 2010
dc.date.issued 2012-04-12
dc.identifier.citation Li, H. W., Nguyen, N. T., Wong, T. N., & Ng, S. L.(2010). Microfluidic on-chip fluorescence-activated interface control system. Biomicrofluidics, 4(4).
dc.identifier.uri http://hdl.handle.net/10220/7749
dc.description.abstract A microfluidic dynamic fluorescence-activated interface control system was developed for lab-on-a-chip applications. The system consists of a straight rectangular microchannel, a fluorescence excitation source, a detection sensor, a signal conversion circuit, and a high-voltage feedback system. Aqueous NaCl as conducting fluid and aqueous glycerol as nonconducting fluid were introduced to flow side by side into the straight rectangular microchannel. Fluorescent dye was added to the aqueous NaCl to work as a signal representing the interface position. Automatic control of the liquid interface was achieved by controlling the electroosmotic effect that exists only in the conducting fluid using a high-voltage feedback system. A LABVIEW program was developed to control the output of high-voltage power supply according the actual interface position, and then the interface position is modified as the output of high-voltage power supply. At last, the interface can be moved to the desired position automatically using this feedback system. The results show that the system presented in this paper can control an arbitrary interface location in real time. The effects of viscosity ratio, flow rates, and polarity of electric field were discussed. This technique can be extended to switch the sample flow and droplets automatically.
dc.format.extent 14 p.
dc.language.iso en
dc.relation.ispartofseries Biomicrofluidics
dc.rights © 2010 American Institute of Physics. This paper was published in Biomicrofluidics and is made available as an electronic reprint (preprint) with permission of American Institute of Physics. The paper can be found at the following: http://link.aip.org.ezlibproxy1.ntu.edu.sg/link/doi/10.1063/1.3516036. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
dc.subject DRNTU::Engineering::Mechanical engineering.
dc.title Microfluidic on-chip fluorescence-activated interface control system
dc.type Journal Article
dc.contributor.school School of Mechanical and Aerospace Engineering
dc.identifier.doi http://link.aip.org.ezlibproxy1.ntu.edu.sg/link/doi/10.1063/1.3516036
dc.description.version Published version

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