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Low-pressure, high-temperature thermal bonding of polymeric microfluidic devices and their applications for electrophoretic separation

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Low-pressure, high-temperature thermal bonding of polymeric microfluidic devices and their applications for electrophoretic separation

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dc.contributor.author Sun, Yi
dc.contributor.author Kwok, Yien Chian
dc.contributor.author Nguyen, Nam-Trung
dc.date.accessioned 2012-05-08T03:09:32Z
dc.date.available 2012-05-08T03:09:32Z
dc.date.copyright 2006
dc.date.issued 2012-05-08
dc.identifier.citation Sun, Y., Kwok, Y. C., & Nguyen, N. T. (2006). Low-pressure, high-temperature thermal bonding of polymeric microfluidic devices and their applications for electrophoretic separation. Journal of Micromechanics and Microengineering, 16(8).
dc.identifier.uri http://hdl.handle.net/10220/7818
dc.description.abstract A new method for thermally bonding poly(methyl methacrylate) (PMMA) substrates has been demonstrated. PMMA substrates are first engraved by CO2-laser micromachining to form microchannels. Both channel width and depth can be adjusted by varying the laser power and scanning speed. Channel depths from 50 µm to 1500 µm and widths from 150 µm to 400 µm are attained. CO2 laser is also used for drilling and dicing of the PMMA parts. Considering the thermal properties of PMMA, a novel thermal bonding process with high temperature and low bonding pressure has been developed for assembling PMMA sheets. A high bonding strength of 2.15 MPa is achieved. Subsequent inspection of the cross sections of several microdevices reveals that the dimensions of the channels are well preserved during the bonding process. Electroosmotic mobility of the ablated channel is measured to be 2.47 × 10−4 cm2 V−1 s−1. The functionality of these thermally bonded microfluidic substrates is demonstrated by performing rapid and high-resolution electrophoretic separations of mixture of fluorescein and carboxyfluorescein as well as double-stranded DNA ladders (ΦX174-Hae III dsDNA digest). The performance of the CO2 laser ablated and thermally bonded PMMA devices compares favorably with those fabricated by other professional means.
dc.format.extent 22 p.
dc.language.iso en
dc.relation.ispartofseries Journal of micromechanics and microengineering
dc.rights © 2006 IOP Publishing Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of micromechanics and microengineering, IOP Publishing Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/ 10.1088/0960-1317/16/8/033 ].
dc.subject DRNTU::Engineering::Mechanical engineering.
dc.title Low-pressure, high-temperature thermal bonding of polymeric microfluidic devices and their applications for electrophoretic separation
dc.type Journal Article
dc.contributor.school School of Mechanical and Aerospace Engineering
dc.identifier.doi http://dx.doi.org/ 10.1088/0960-1317/16/8/033
dc.description.version Accepted version
dc.identifier.rims 91938

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