Faster and improved microchip electrophoresis using a capillary bundle

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Faster and improved microchip electrophoresis using a capillary bundle

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dc.contributor.author Sun, Yi
dc.contributor.author Kwok, Yien Chian
dc.contributor.author Nguyen, Nam-Trung
dc.date.accessioned 2012-05-10T02:47:18Z
dc.date.available 2012-05-10T02:47:18Z
dc.date.copyright 2007
dc.date.issued 2012-05-10
dc.identifier.citation Sun, Y., Kwok, Y. C., & Nguyen, N. T. (2007). Faster and Improved Microchip Electrophoresis Using a Capillary Bundle. Electrophoresis, 28(24), 4765-4768.
dc.identifier.uri http://hdl.handle.net/10220/7832
dc.description.abstract Joule heating generated in capillary electrophoresis (CE) microchips is known to affect temperature gradient, electrophoretic mobility, diffusion of analytes, and ultimately the efficiency and reproducibility of the separation. One way of reducing the effect of Joule heating is to decrease the cross-section area of microchannels. Currently, due to the limit of fabrication technique and detection apparatus, the typical dimensions of CE microchannels are in the range of 50 μm to 200 μm. In this paper, we propose a novel approach of performing microchip CE in a bundle of extremely narrow channels by using photonic crystal fiber (PCF) as separation column. The PCF was simply encapsulated in a polymethylmethacrylate (PMMA) microchannel right after a T-shaped injector. CE was simultaneously but independently carried out in 54 narrow capillaries, each capillary with diameter of 3.7 μm. The capillary bundle could sustain high electric field strength up to 1000 V/cm due to efficient heat dissipation, thus faster and enhanced separation was attained.
dc.format.extent 12 p.
dc.language.iso en
dc.relation.ispartofseries Electrophoresis
dc.rights © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.subject DRNTU::Engineering::Mechanical engineering.
dc.title Faster and improved microchip electrophoresis using a capillary bundle
dc.type Journal Article
dc.contributor.school School of Mechanical and Aerospace Engineering
dc.identifier.doi http://dx.doi.org/10.1002/elps.200700259
dc.identifier.rims 92800

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