mirage

Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors

DSpace/Manakin Repository

 

Search DR-NTU


Advanced Search Subject Search

Browse

My Account

Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors

Show simple item record

dc.contributor.author Zhu, Pengcheng
dc.contributor.author Tan, Ming Jie
dc.contributor.author Huang, Royston-Luke
dc.contributor.author Tan, Chek Kun
dc.contributor.author Chong, Han Chung
dc.contributor.author Pal, Mintu
dc.contributor.author Lam, Ivan Chee Ren
dc.contributor.author Boukamp, Petra
dc.contributor.author Pan, Jiun Yit
dc.contributor.author Tan, Suat Hoon
dc.contributor.author Kersten, Sander
dc.contributor.author Li, Hoi-Yeung
dc.contributor.author Ding, Jeak Ling
dc.contributor.author Tan, Nguan Soon
dc.date.accessioned 2012-05-29T08:21:55Z
dc.date.available 2012-05-29T08:21:55Z
dc.date.copyright 2011
dc.date.issued 2012-05-29
dc.identifier.citation Zhu, P., Tan, M. J., Huang, R. L., Tan, C. K., Chong, H. C., Pal, M., et al. (2011). Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2(-): H2O2 Ratio and Confers Anoikis Resistance to Tumors. Cancer cell, 19(3), 401-415.
dc.identifier.uri http://hdl.handle.net/10220/8177
dc.description.abstract Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O2(-). A high ratio of O2:(-)H2O2 oxidizes/activates Src, triggering the PI3K/PKBα and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O2(-) production and a reduced O2:(-)H2O2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target.
dc.format.extent 15 p.
dc.language.iso en
dc.relation.ispartofseries Cancer cell
dc.rights © 2011 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Cancer Cell, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1016/j.ccr.2011.01.018 ]
dc.subject DRNTU::Science::Biological sciences::Cytology.
dc.title Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1016/j.ccr.2011.01.018

Files in this item

Files Size Format View
Accepted_Angiop ... s Resistance to Tumors.pdf 5.061Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Statistics

Total views

All Items Views
Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors 449

Total downloads

All Bitstreams Views
Accepted_Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O-2(-)H2O2 Ratio and Confers Anoikis Resistance to Tumors.pdf 312
Zhu et al (Cancer Cell 2011-03).pdf 10

Top country downloads

Country Code Views
United States of America 136
Singapore 47
China 38
Germany 14
India 10

Top city downloads

city Views
Mountain View 116
Singapore 39
Beijing 8
Kiez 5
Bangkok 4