Angiopoietin-like 4 : a decade of research

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Angiopoietin-like 4 : a decade of research

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dc.contributor.author Zhu, Pengcheng
dc.contributor.author Goh, Yan Yih
dc.contributor.author Chin, Alison Hwee Fang
dc.contributor.author Kersten, Sander
dc.contributor.author Tan, Nguan Soon
dc.date.accessioned 2012-05-31T09:19:44Z
dc.date.available 2012-05-31T09:19:44Z
dc.date.copyright 2012
dc.date.issued 2012-05-31
dc.identifier.citation Zhu, P., Goh, Y. Y., Chin, A. H. F., Kersten, S., & Tan, N. S. (2012). Angiopoietin-like 4: a decade of research. Bioscience Reports, 32, 211–219.
dc.identifier.uri http://hdl.handle.net/10220/8184
dc.description.abstract The past decade has seen a rapid development and increasing recognition of ANGPTL4 (angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic and non-metabolic conditions. ANGPTL4 has been recognised as a central player in various aspects of energy homoeostasis, at least in part, via the inhibitory interaction between the coiled-coil domain of ANGPTL4 and LPL (lipoprotein lipase). The fibrinogen-like domain of ANGPTL4 interacts and activates specific integrins to facilitate wound healing, modulates vascular permeability, and regulates ROS (reactive oxygen species) level to promote tumorigenesis. The present review summarizes these landmark findings about ANGPTL4 and highlights several important implications for future clinical practice. Importantly, these implications have also raised many questions that are in urgent need of further investigations, particularly the transcription regulation of ANGPTL4 expression, and the post-translation cleavage and modifications of ANGPTL4. The research findings over the past decade have laid the foundation for a better mechanistic understanding of the new scientific discoveries on the diverse roles of ANGPTL4.
dc.language.iso en
dc.relation.ispartofseries Bioscience reports
dc.rights © The Authors Journal compilation © 2012 Biochemical Society.
dc.subject DRNTU::Science::Biological sciences
dc.title Angiopoietin-like 4 : a decade of research
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1042/BSR20110102
dc.identifier.rims 162094

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