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Emerging roles of angiopoietin-like 4 in human cancer

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Emerging roles of angiopoietin-like 4 in human cancer

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dc.contributor.author Tan, Ming Jie
dc.contributor.author Teo, Ziqiang
dc.contributor.author Sng, Ming Keat
dc.contributor.author Zhu, Pengcheng
dc.contributor.author Tan, Nguan Soon
dc.date.accessioned 2012-07-04T09:21:40Z
dc.date.available 2012-07-04T09:21:40Z
dc.date.copyright 2012
dc.date.issued 2012-07-04
dc.identifier.citation Tan, M. J., Teo, Z., Sng, M. K., Zhu, P., & Tan, N. S. (2012). Emerging Roles of Angiopoietin-like 4 in Human Cancer. Molecular Cancer Research, 10(6), 677-688.
dc.identifier.issn 1557-3125(electronic)
dc.identifier.uri http://hdl.handle.net/10220/8287
dc.description.abstract Angiopoietin-like 4 (ANGPTL4) is best known for its role as an adipokine involved in the regulation of lipid and glucose metabolism. The characterization of ANGPTL4 as an adipokine is largely due to our limited understanding of the interaction partners of ANGPTL4 and how ANGPTL4 initiates intracellular signaling. Recent findings have revealed a critical role for ANGPTL4 in cancer growth and progression, anoikis resistance, altered redox regulation, angiogenesis, and metastasis. Emerging evidence suggests that ANGPTL4 function may be drastically altered depending on the proteolytic processing and posttranslational modifications of ANGPTL4, which may clarify several conflicting roles of ANGPTL4 in different cancers. Although the N-terminal coiled-coil region of ANGPTL4 has been largely responsible for the endocrine regulatory role in lipid metabolism, insulin sensitivity, and glucose homeostasis, it has now emerged that the COOH-terminal fibrinogen-like domain of ANGPTL4 may be a key regulator in the multifaceted signaling during cancer development. New insights into the mechanistic action of this functional domain have opened a new chapter into the possible clinical application of ANGPTL4 as a promising candidate for clinical intervention in the fight against cancer. This review summarizes our current understanding of ANGPTL4 in cancer and highlights areas that warrant further investigation. A better understanding of the underlying cellular and molecular mechanisms of ANGPTL4 will reveal novel insights into other aspects of tumorigenesis and the potential therapeutic value of ANGPTL4.
dc.format.extent 43 p.
dc.language.iso en
dc.relation.ispartofseries Molecular cancer research
dc.rights © 2012 American Association for Cancer Research. This is the author created version of a work that has been peer reviewed and accepted for publication by Molecular Cancer Research, American Association for Cancer Research. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: DOI: [http://dx.doi.org/10.1158/1541-7786.MCR-11-0519].
dc.subject DRNTU::Science::Biological sciences::Molecular biology
dc.title Emerging roles of angiopoietin-like 4 in human cancer
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1158/1541-7786.MCR-11-0519
dc.description.version Accepted version

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