mirage

Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells

DSpace/Manakin Repository

 

Search DR-NTU


Advanced Search Subject Search

Browse

My Account

Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells

Show simple item record

dc.contributor.author Choi, Bo-Hwa
dc.contributor.author Kim, Wanil
dc.contributor.author Wang, Qiuxia Chelsia
dc.contributor.author Kim, Dong-Chan
dc.contributor.author Tan, Swee Ngin
dc.contributor.author Yong, Jean Wan Hong
dc.contributor.author Kim, Kyong-Tai
dc.contributor.author Yoon, Ho Sup
dc.date.accessioned 2012-08-14T04:21:28Z
dc.date.available 2012-08-14T04:21:28Z
dc.date.copyright 2007
dc.date.issued 2012-08-14
dc.identifier.citation Choi, B. -H., Kim, W., Wang, Q. C., Kim, D., -C., Tan, S., N., Yong, J. W. H., et al. (2008). Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Letters, 261(1), 37-45.
dc.identifier.uri http://hdl.handle.net/10220/8384
dc.description.abstract Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while Bcl-2 was down-regulated under KR exposure. A tumor growth in mice was dramatically suppressed by KR. In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-XL, and cleaved PARP were observed. Our data suggest that KR selectively induces apoptosis in cancer cells through the classical mitochondria dependent apoptosis pathway.
dc.language.iso en
dc.relation.ispartofseries Cancer letters
dc.rights © 2007 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Cancer Letters, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1016/j.canlet.2007.11.014.
dc.subject DRNTU::Science::Biological sciences.
dc.title Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1016/j.canlet.2007.11.014
dc.description.version Accepted version

Files in this item

Files Size Format View
14.Kinetin ribo ... osis by modulating Bcl.pdf 404.6Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Statistics

Total views

All Items Views
Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells 307

Total downloads

All Bitstreams Views
14.Kinetin riboside preferentially induces apoptosis by modulating Bcl.pdf 314

Top country downloads

Country Code Views
United States of America 131
China 68
Singapore 18
Indonesia 16
Germany 14

Top city downloads

city Views
Mountain View 91
Beijing 41
Singapore 17
Manado 6
Surabaya 6