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Osteoblast interactions with various hydroxyapatite based biomaterials consolidated using a spark plasma sintering technique.

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Osteoblast interactions with various hydroxyapatite based biomaterials consolidated using a spark plasma sintering technique.

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dc.contributor.author Xu, Jinling.
dc.contributor.author Khor, Khiam Aik.
dc.contributor.author Lu, Y. W.
dc.contributor.author Chen Wei Ning, William.
dc.contributor.author Kumar, R.
dc.date.accessioned 2012-08-24T03:31:31Z
dc.date.available 2012-08-24T03:31:31Z
dc.date.copyright 2007
dc.date.issued 2012-08-24
dc.identifier.citation Xu, J. L., Khor, K. A., Lu, Y. W., Chen, W. N. W., & Kumar, R. (2007). Osteoblast interactions with various hydroxyapatite based biomaterials consolidated using a spark plasma sintering technique. Journal of biomedical materials research part B : applied biomaterials, 84B(1), 224-230.
dc.identifier.issn 1552-4981
dc.identifier.uri http://hdl.handle.net/10220/8421
dc.description.abstract This study investigated the osteoblast behaviors on various hydroxyapatite based biomaterials that were consolidated at 1100°C for 3 min by a spark plasma sintering technique. The osteoblasts from human fetal osteoblast cell line were cultured in the medium on the various biomaterials surfaces (HA, RF21, 1SiHA, and 5SiHA) to assess the cell morphology and proliferation as well as cell differentiation (alkaline phosphatase activity). Moreover, the bone -carboxyglutamic protein or osteocalcin in the medium were determined at different periods of culture. The present results indicated that the amount of osteocalcin in the medium decreased during the periods of culture. The highest osteocalcin production obtained from the biomaterial 5SiHA after cell culture for 2 days demonstrated that the presence of silica in the biomaterials enhanced the cell differentiation by the rapid release of silicate and calcium ions.
dc.language.iso en
dc.relation.ispartofseries Journal of biomedical materials research Part B: applied biomaterials
dc.rights © 2007 Wiley Periodicals, Inc.
dc.subject DRNTU::Engineering::Materials::Biomaterials.
dc.title Osteoblast interactions with various hydroxyapatite based biomaterials consolidated using a spark plasma sintering technique.
dc.type Journal Article
dc.contributor.school School of Mechanical and Aerospace Engineering
dc.identifier.doi http://dx.doi.org/10.1002/jbm.b.30864

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