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Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution

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Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution

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Title: Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution
Author: Zhang, Juan; Wang, Lihua; Zhang, Hua; Boey, Freddy Yin Chiang; Song, Shiping; Fan, Chunhai
Copyright year: 2010
Abstract: The design of a novel multicolor fluorescent gold nanoprobe for homogeneous detection of small-molecule targets is reported, which combines the specific binding abilities of aptamers with the ultrahigh quenching ability of gold nanoparticles (AuNPs). Dye-tagged aptamers and their complementary sequence with thiol labels are co-assembled at the surface of AuNPs. As a proof of concept, it is demonstrated that such a multicolor fluorescent gold nanoprobe can simultaneously detect adenosine, potassium ion, and cocaine with high selectivity. This potentially generic strategy is shown to be promising for rapid screening of small molecular targets.
Subject: DRNTU::Engineering::Materials.
Type: Journal Article
Series/ Journal Title: Small
School: School of Materials Science and Engineering
Rights: © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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