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Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution

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Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution

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dc.contributor.author Zhang, Juan
dc.contributor.author Wang, Lihua
dc.contributor.author Zhang, Hua
dc.contributor.author Boey, Freddy Yin Chiang
dc.contributor.author Song, Shiping
dc.contributor.author Fan, Chunhai
dc.date.accessioned 2012-09-20T01:13:40Z
dc.date.available 2012-09-20T01:13:40Z
dc.date.copyright 2010
dc.date.issued 2012-09-20
dc.identifier.citation Zhang, J., Wang, L., Zhang, H., Boey, F. Y. C., Song, S., & Fan, C. (2010). Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution. Small, 6(2), 201-204.
dc.identifier.issn 1613-6829
dc.identifier.uri http://hdl.handle.net/10220/8584
dc.description.abstract The design of a novel multicolor fluorescent gold nanoprobe for homogeneous detection of small-molecule targets is reported, which combines the specific binding abilities of aptamers with the ultrahigh quenching ability of gold nanoparticles (AuNPs). Dye-tagged aptamers and their complementary sequence with thiol labels are co-assembled at the surface of AuNPs. As a proof of concept, it is demonstrated that such a multicolor fluorescent gold nanoprobe can simultaneously detect adenosine, potassium ion, and cocaine with high selectivity. This potentially generic strategy is shown to be promising for rapid screening of small molecular targets.
dc.language.iso en
dc.relation.ispartofseries Small
dc.rights © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.subject DRNTU::Engineering::Materials.
dc.title Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution
dc.type Journal Article
dc.contributor.school School of Materials Science and Engineering
dc.identifier.doi http://dx.doi.org/10.1002/smll.200901012

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