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Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures

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Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures

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Title: Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures
Author: Zhang, Juan; Wang, Lihua; Pan, Dun; Song, Shiping; Boey, Freddy Yin Chiang; Zhang, Hua; Fan, Chunhai
Copyright year: 2008
Abstract: A novel bioassay strategy is designed to detect small-molecule targets such as cocaine, potassium, and adenosine, based on gold nanoparticles (AuNPs) and engineered DNA aptamers. In this design, an aptamer is engineered to be two pieces of random, coil-like single-stranded DNA, which reassembles into the intact aptamer tertiary structure in the presence of the specific target. AuNPs can effectively differentiate between these two states via their characteristic surface-plasmon resonance-based color change. Using this method, cocaine in the low-micromolar range is selectively detected within minutes. This strategy is also shown to be generic and applicable to the detection of several other small-molecule targets.
Subject: DRNTU::Engineering::Materials.
Type: Journal Article
Series/ Journal Title: Small
School: School of Materials Science and Engineering
Rights: © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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