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Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures

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Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures

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dc.contributor.author Zhang, Juan
dc.contributor.author Wang, Lihua
dc.contributor.author Pan, Dun
dc.contributor.author Song, Shiping
dc.contributor.author Boey, Freddy Yin Chiang
dc.contributor.author Zhang, Hua
dc.contributor.author Fan, Chunhai
dc.date.accessioned 2012-09-24T01:00:02Z
dc.date.available 2012-09-24T01:00:02Z
dc.date.copyright 2008
dc.date.issued 2012-09-24
dc.identifier.citation Zhang, J., Wang, L., Pan, D., Song, S., Boey, F. Y. C., Zhang, H., et al. (2008). Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures. Small, 4(8), 1196-1200.
dc.identifier.issn 1613-6829
dc.identifier.uri http://hdl.handle.net/10220/8604
dc.description.abstract A novel bioassay strategy is designed to detect small-molecule targets such as cocaine, potassium, and adenosine, based on gold nanoparticles (AuNPs) and engineered DNA aptamers. In this design, an aptamer is engineered to be two pieces of random, coil-like single-stranded DNA, which reassembles into the intact aptamer tertiary structure in the presence of the specific target. AuNPs can effectively differentiate between these two states via their characteristic surface-plasmon resonance-based color change. Using this method, cocaine in the low-micromolar range is selectively detected within minutes. This strategy is also shown to be generic and applicable to the detection of several other small-molecule targets.
dc.language.iso en
dc.relation.ispartofseries Small
dc.rights © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.subject DRNTU::Engineering::Materials.
dc.title Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures
dc.type Journal Article
dc.contributor.school School of Materials Science and Engineering
dc.identifier.doi http://dx.doi.org/10.1002/smll.200800057

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