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Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method.

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Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method.

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dc.contributor.author Xu, Jinling.
dc.contributor.author Khor, Khiam Aik.
dc.date.accessioned 2012-10-01T08:05:31Z
dc.date.available 2012-10-01T08:05:31Z
dc.date.copyright 2006
dc.date.issued 2012-10-01
dc.identifier.citation Xu, J., & Khor, K. A. (2007). Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method. Journal of Inorganic Biochemistry, 101(2), 187-195.
dc.identifier.issn 0162-0134
dc.identifier.uri http://hdl.handle.net/10220/8683
dc.description.abstract Silica (SiO2) and the silicate-based biomaterials play an important role due to their in vitro and in vivo biological response. The present study synthesized a novel nano-structured amorphous silica doped hydroxyapatite (HA) via an aqueous precipitation route. HA was prepared with 0, 1, 3 and 5 wt% silica, which are comparable to the measured silicon content of natural bone. After spray drying into micron sized powders, the silica doped HA (SiHA) powders were consolidated at 1000 C with a dwell time of 3 min using a spark plasma sintering (SPS) technique. X-ray diffraction analysis showed a main apatite phase with minor secondary b-tricalcium phosphate (b-TCP) was observed in the as-consolidated SiHA compacts. Substitution of PO3- 4 by SiO4- 4 in the apatite structure resulting in a small increase in the lattice parameters in both a-axis and c-axis of the unit cell were identified by X-ray photoelectron spectrometer (XPS) analysis and Raman spectrometer investigation. The cell culture in vitro investigation demonstrated that the presence of silicon in the SPS consolidated compacts contributed to the relatively high cell proliferation ability when compared with phase pure HA.
dc.language.iso en
dc.relation.ispartofseries Journal of inorganic biochemistry
dc.rights © 2006 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Inorganic Biochemistry, Elsevier Inc.. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: DOI: [http://dx.doi.org/10.1016/j.jinorgbio.2006.09.030].
dc.subject DRNTU::Science::Chemistry::Inorganic chemistry.
dc.title Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method.
dc.type Journal Article
dc.contributor.school School of Mechanical and Aerospace Engineering
dc.identifier.doi http://dx.doi.org/10.1016/j.jinorgbio.2006.09.030
dc.description.version Accepted version

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