mirage

Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins

DSpace/Manakin Repository

 

Search DR-NTU


Advanced Search Subject Search

Browse

My Account

Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins

Show simple item record

dc.contributor.author Ha, Ji-Hyang
dc.contributor.author Won, Eun-Young
dc.contributor.author Shin, Jae-Sun
dc.contributor.author Jang, Mi
dc.contributor.author Ryu, Kyoung-Seok
dc.contributor.author Baek, Kwanghee
dc.contributor.author Park, Sung Goo
dc.contributor.author Park, Byoung Chul
dc.contributor.author Yoon, Ho Sup
dc.contributor.author Chi, Seung-Wook
dc.date.accessioned 2012-10-09T06:11:44Z
dc.date.available 2012-10-09T06:11:44Z
dc.date.copyright 2011
dc.date.issued 2012-10-09
dc.identifier.citation Ha, J. H., Won, E. Y., Shin, J. S., Jang, M., Ryu, K. S., Baek, K., et al. (2011). Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins. Journal of the American chemical society, 133(5), 1244-1247.
dc.identifier.uri http://hdl.handle.net/10220/8736
dc.description.abstract The identification of off-target binding of drugs is a key to repositioning drugs to new therapeutic categories. Here we show the universal interactions of the p53 transactivation domain (p53TAD) with various antiapoptotic Bcl-2 family proteins via a mouse double minute 2 (MDM2) binding motif, which play an important role in transcription-independent apoptotic pathways of p53. Interestingly, our structural studies reveal that the anti-apoptotic Bcl-2 family proteins and MDM2 share a similar mode of interaction with the p53TAD. On the basis of this close molecular mimicry, our NMR results demonstrate that the potent MDM2 antagonists Nutlin-3 and PMI bind to the anti-apoptotic Bcl-2 family proteins in a manner analogous to that with the p53TAD.
dc.language.iso en
dc.relation.ispartofseries Journal of the American chemical society
dc.rights © 2011 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of the American Chemical Society , American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1021/ja109521f.
dc.subject DRNTU::Science::Biological sciences.
dc.title Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins
dc.type Journal Article
dc.contributor.school School of Biological Sciences
dc.identifier.doi http://dx.doi.org/10.1021/ja109521f
dc.description.version Accepted version

Files in this item

Files Size Format View
4. Molecular Mi ... Bcl-2 Family Proteins.pdf 663.4Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Statistics

Total views

All Items Views
Molecular mimicry-based repositioning of Nutlin-3 to anti-apoptotic Bcl-2 family proteins 205

Total downloads

All Bitstreams Views
4. Molecular Mimicry-Based Repositioning of Nutlin-3 to Anti-Apoptotic Bcl-2 Family Proteins.pdf 139

Top country downloads

Country Code Views
United States of America 69
China 17
Singapore 15
Korea 10
Japan 4

Top city downloads

city Views
Mountain View 53
Beijing 13
Singapore 13
Seoul 9
Redwood City 5