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CMOS high density electrical impedance biosensor array for tumor cell detection

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CMOS high density electrical impedance biosensor array for tumor cell detection

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dc.contributor.author Chen, Yu
dc.contributor.author Wong, Chee Chung
dc.contributor.author Pui, Tze Sian
dc.contributor.author Nadipalli, Revanth
dc.contributor.author Weerasekera, Roshan
dc.contributor.author Chandran, Jegatha
dc.contributor.author Yu, Hao
dc.contributor.author Rahman, Abdur Rub Abdur
dc.date.accessioned 2012-10-25T04:13:29Z
dc.date.available 2012-10-25T04:13:29Z
dc.date.copyright 2012
dc.date.issued 2012-10-25
dc.identifier.citation Chen, Y., Wong, C. C., Pui, T. S., Nadipalli, R., Weerasekera, R., Chandran, J., et al. (2012). CMOS high density electrical impedance biosensor array for tumor cell detection. Sensors and actuators B : chemical, 173, 903-907.
dc.identifier.issn 09254005
dc.identifier.uri http://hdl.handle.net/10220/8797
dc.description.abstract We present a high-throughput label-free electrical-impedance spectroscopy (EIS) platform composed of a 96 × 96 microelectrode array for counting and analysis of breast tumor cells (MCF-7). These Auelectrodes are densely packed within a 3.5 mm × 3.5 mm interrogation region. Each Au-electrode has an edge-length of 25 μm designed to detect single tumor cell by electrical impedance spectroscopy. The detected signal is read out via an integrated circuit (IC) of addressable electrode-selection-switch array manufactured with 0.18μm CMOS technology. The independently addressable microelectrode array is integrated onto a printed circuit board (PCB) containing associated circuitry for electrode switching and readout. MCF-7 cells were dispensed onto the chip surface and EIS measurements were recorded before and after the cell dispensation. On an average 20% increase in impedance was found associated with cell occupancy on the electrode surface. A positive correlation was observed between cell detection with optical microscopy and with electrical scanning.
dc.language.iso en
dc.relation.ispartofseries Sensors and actuators B : chemical
dc.rights © 2012 Elsevier B. V. This is the author created version of a work that has been peer reviewed and accepted for publication by Sensors and actuators B: chemical, Elsevier B. V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: http://dx.doi.org/10.1016/j.snb.2012.07.024.
dc.subject DRNTU::Engineering::Electrical and electronic engineering.
dc.title CMOS high density electrical impedance biosensor array for tumor cell detection
dc.type Journal Article
dc.contributor.school School of Electrical and Electronic Engineering
dc.identifier.doi http://dx.doi.org/10.1016/j.snb.2012.07.024
dc.description.version Accepted version

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