Browsing by Author Dick, Thomas

Showing results 1 to 16 of 16
Issue DateTitleAuthor(s)
 20181,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activityYang, Xuan; Wedajo, Wassihun; Yamada, Yoshiyuki; Dahlroth, Sue-Li; Neo, Jason Jun-Long; Dick, Thomas; Chui, Wai-Keung
2020Antituberculosis activity of the antimalaria cytochrome bcc oxidase inhibitor SCR0911Chong, Sherilyn Shi Min; Manimekalai, Malathy Sony Subramanian; Sarathy, Jickky Palmae; Williams, Zoe C.; Harold, Liam K.; Cook, Gregory M.; Dick, Thomas; Pethe, Kevin; Bates, Roderick Wayland; Grüber, Gerhard
2016Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP SynthaseKundu, Subhashri; Biukovic, Goran; Grüber, Gerhard; Dick, Thomas
2016Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis-driven H+ pumpingHotra, Adam; Suter, Manuel; Biuković, Goran; Priya, Ragunathan; Kundu, Subhashri; Dick, Thomas; Grüber, Gerhard
2019Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesisSaw, Wuan-Geok; Wu, Mu-Lu; Ragunathan, Priya; Biuković, Goran; Lau, Aik-Meng; Shin, Joon; Harikishore, Amaravadhi; Cheung, Chen-Yi; Hards, Kiel; Sarathy, Jickky Palmae; Bates, Roderick Wayland; Cook, Gregory M.; Dick, Thomas; Grüber, Gerhard
2018The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit ε provides new insight into energy coupling inside the rotary engineJoon, Shin; Ragunathan, Priya; Sundararaman, Lavanya; Nartey, Wilson; Kundu, Subhashri; Manimekalai, Malathy Sony Subramanian; Bogdanović, Nebojša; Dick, Thomas; Grüber, Gerhard
2018Novel acetamide indirectly targets mycobacterial transporter MmpL3 by proton motive force disruptionShetty, Annanya; Xu, Zhujun; Lakshmanan, Umayal; Hill, Jeffrey; Choong, Meng Ling; Chng, Shu-Sin; Yamada, Yoshiyuki; Poulsen, Anders; Dick, Thomas; Gengenbacher, Martin
2019Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthaseSaw, Wuan-Geok; Wong, Chui-Fann; Dick, Thomas; Grüber, Gerhard
2020Pyrazinamide triggers degradation of its target aspartate decarboxylaseGopal, Pooja; Sarathy, Jickky Palmae; Yee, Michelle; Ragunathan, Priya; Shin, Joon; Bhushan, Shashi; Zhu, Junhao; Akopian, Tatos; Kandror, Olga; Lim, Teck Kwang; Gengenbacher, Martin; Lin, Qingsong; Rubin, Eric J.; Grüber, Gerhard; Dick, Thomas
2019Re-understanding the mechanisms of action of the anti-mycobacterial drug bedaquilineSarathy, Jickky Palmae; Gruber, Gerhard; Dick, Thomas
2018Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and εBogdanović, Nebojša; Sundararaman, Lavanya; Kamariah, Neelagandan; Tyagi, Anu; Bhushan, Shashi; Ragunathan, Priya; Shin, Joon; Dick, Thomas; Grüber, Gerhard
2020TBAJ-876 displays bedaquiline-like mycobactericidal potency without retaining the parental drug’s uncoupler activitySarathy, Jickky Palmae; Ragunathan, Priya; Cooper, Christopher B.; Upton, Anna M.; Grüber, Gerhard; Dick, Thomas
2019TBAJ-876 retains bedaquiline’s activity against subunits c and ε of mycobacterium tuberculosis F-ATP synthaseSarathy, Jickky Palmae; Ragunathan, Priya; Shin, Joon; Cooper, Christopher B.; Upton, Anna M.; Grüber, Gerhard; Dick, Thomas
2019Unique structural and mechanistic properties of mycobacterial F-ATP synthases : implications for drug designKamariah, Neelagandan; Ragunathan, Priya; Shin, Joon; Saw, Wuan-Geok; Wong, Chui-Fann; Dick, Thomas; Grüber, Gerhard
2017The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptationRagunathan, Priya; Sielaff, Hendrik; Sundararaman, Lavanya; Biuković, Goran; Subramanian Manimekalai, Malathy Sony; Singh, Dhirendra; Kundu, Subhashri; Wohland, Thorsten; Frasch, Wayne; Dick, Thomas; Grüber, Gerhard
 2013Variations of subunit ε of the mycobacterium tuberculosis F1Fo ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207Rao, Srinivasa P. S.; Biuković, Goran; Basak, Sandip; Manimekalai, Malathy Sony Subramanian; Rishikesan, Sankaranarayanan; Roessle, Manfred; Dick, Thomas; Hunke, Cornelia; Grüber, Gerhard