Browsing by Author Eisenhaber, Birgit

Showing results 1 to 16 of 16
Issue DateTitleAuthor(s)
 2018Active site CP-loop dynamics modulate substrate binding, catalysis, oligomerization, stability, over-oxidation and recycling of 2-Cys PeroxiredoxinsKamariah, Neelagandan; Eisenhaber, Birgit; Eisenhaber, Frank; Grüber, Gerhard
 2012Beware of moving tagerts: reference proteome content fluctuates substantially over the yearsSirota, Fernanda L.; Batagov, Arsen; Schneider, Georg; Eisenhaber, Birgit; Eisenhaber, Frank; Maurer-Stroh, Sebastian
2017Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”Baker, James Alexander; Wong, Wing-Cheong; Eisenhaber, Birgit; Warwicker, Jim; Eisenhaber, Frank
2021Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sitesEisenhaber, Birgit; Sinha, Swati; Jadalanki, Chaitanya K.; Shitov, Vladimir A.; Tan, Qiao Wen; Sirota, Fernanda L.; Eisenhaber, Frank
2018Darkness in the human gene and protein function space : widely modest or absent illumination by the life science literature and the trend for fewer protein function discoveries since 2000Sinha, Swati; Eisenhaber, Birgit; Jensen, Lars Juhl; Kalbuaji, Bharata; Eisenhaber, Frank
2015dissectHMMER: a HMMER-based score dissection framework that statistically evaluates fold-critical sequence segments for domain fold similarityWong, Wing-Cheong; Yap, Choon-Kong; Eisenhaber, Birgit; Eisenhaber, Frank
2019Effect of the additional cysteine 503 of vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F (AhpF) and the mechanism of AhpF and subunit C assemblingToh, Yew Kwang; Shin, Joon; Balakrishna, Asha Manikkoth; Kamariah, Neelagandan; Grüber, Ardina; Eisenhaber, Frank; Eisenhaber, Birgit; Grüber, Gerhard
2017Essential role of the flexible linker on the conformational equilibrium of bacterial peroxiredoxin reductase for effective regeneration of peroxiredoxinGrüber, Gerhard; Kamariah, Neelagandan; Eisenhaber, Birgit; Eisenhaber, Frank
2021Functional classification of super-large families of enzymes based on substrate binding pocket residues for biocatalysis and enzyme engineering applicationsSirota, Fernanda L.; Maurer-Stroh, Sebastian; Li, Zhi; Eisenhaber, Frank; Eisenhaber, Birgit
2019Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723Sinha, Swati; Nge, Choy-Eng; Leong, Chung Yan; Ng, Veronica; Crasta, Sharon; Goh, Falicia; Low, Kia-Ngee; Zhang, Huibin; Arumugam, Prakash; Lezhava, Alexander; Chen, Swaine L.; Kanagasundaram, Yoganathan; Ng, Siew Bee; Eisenhaber, Frank; Eisenhaber, Birgit; Mohammad Alfatah
2020Identification and engineering of 32 membered antifungal macrolactone notonesomycinsGoh, Falicia; Zhang, Mingzi M.; Lim, Tian Ru; Low, Kia Ngee; Nge, Choy Eng; Heng, Elena; Yeo, Wan Lin; Sirota, Fernanda L.; Crasta, Sharon; Tan, Zann; Ng, Veronica; Leong, Chung Yan; Zhang, Huibin; Lezhava, Alexander; Chen, Swaine L.; Hoon, Shawn S.; Eisenhaber, Frank; Eisenhaber, Birgit; Kanagasundaram, Yoganathan; Wong, Fong T.; Ng, Siew Bee
2018Molecular mechanism of the Escherichia coli AhpC in the function of a chaperone under heat-shock conditionsKamariah, Neelagandan; Eisenhaber, Birgit; Eisenhaber, Frank; Grüber, Gerhard
2014On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotationWong, Wing-Cheong; Maurer-Stroh, Sebastian; Eisenhaber, Birgit; Eisenhaber, Frank
2020Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active siteSu, Chinh Tran-To; Sinha, Swati; Eisenhaber, Birgit; Eisenhaber, Frank
2016Transition steps in peroxide reduction and a molecular switch for peroxide robustness of prokaryotic peroxiredoxinsKamariah, Neelagandan; Sek, Mun Foong; Eisenhaber, Birgit; Eisenhaber, Frank; Grüber, Gerhard
2016xHMMER3x2: Utilizing HMMER3’s speed and HMMER2’s sensitivity and specificity in the glocal alignment mode for improved large-scale protein domain annotationYap, Choon-Kong; Eisenhaber, Birgit; Eisenhaber, Frank; Wong, Wing-Cheong