Browsing by Author Luo, Dahai


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Issue DateTitleAuthor(s)
20212-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus ProteasePatil, Nitin A.; Quek, Jun-Ping; Schroeder, Barbara; Morewood, Richard; Rademann, Jörg; Luo, Dahai; Nitsche, Christoph
2019Biocompatible macrocyclization between cysteine and 2-cyanopyridine generates stable peptide inhibitorsNitsche, Christoph; Onagi, Hideki; Quek, Jun-Ping; Otting, Gottfried; Luo, Dahai; Huber, Thomas
2016The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus ProductionChan, Kitti W. K.; Tay, Moon Y. F.; Smith, Kate; Ng, Ivan H. W.; Zhao, Yongqian; Ooi, Eng Eong; Lescar, Julien; Luo, Dahai; Jans, David A.; Forwood, Jade K.; Vasudevan, Subhash G.
2014The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replicationTay, Moon Y. F.; Saw, Wuan Geok; Zhao, Yongqian; Chan, Kitti W. K.; Singh, Daljit; Chong, Yuwen; Forwood, Jade K.; Ooi, Eng Eong; Grüber, Gerhard; Lescar, Julien; Luo, Dahai; Vasudevan, Subhash G.
 2019Cell-active carbazole derivatives as inhibitors of the zika virus proteaseRassias, Gerasimos; Zogali, Vasiliki; Swarbrick, Crystall M. D.; Chan, Kitti Wing Ki; Chan, Shu Ann; Gwee, Chin Piaw; Wang, Sai; Kaplanai, Entzy; Canko, Aleksander; Kiousis, Dimitrios; Lescar, Julien; Luo, Dahai; Matsoukas, Minos-Timotheos; Vasudevan, Subhash G.
2017Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activitiesChen, Ming Wei; Tan, Yaw Bia; Zheng, Jie; Zhao, Yongqian; Lim, Bee Ting; Cornvik, Tobias; Lescar, Julien; Ng, Lisa Fong Poh; Luo, Dahai
2015A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replicationZhao, Yongqian; Soh, Tingjin Sherryl; Zheng, Jie; Chan, Kitti Wing Ki; Phoo, Wint Wint; Lee, Chin Chin; Tay, Moon Y. F.; Swaminathan, Kunchithapadam; Cornvik, Tobias Carl; Lim, Siew Pheng; Shi, Pei-Yong; Lescar, Julien; Vasudevan, Subhash G.; Luo, Dahai
2016Crystal structure of unlinked NS2B-NS3 protease from Zika virusZhang, Zhenzhen; Li, Yan; Loh, Ying Ru; Phoo, Wint Wint; Hung, Alvin W.; Kang, CongBao; Luo, Dahai
 2020Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3Phoo, Wint Wint; El Sahili, Abbas; Zhang, ZhenZhen; Chen, Ming Wei; Liew, Chong Wai; Lescar, Julien; Vasudevan, Subhash G.; Luo, Dahai
2015The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug developmentLuo, Dahai; Vasudevan, Subhash; Lescar, Julien
2015Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus ReplicationZhao, Yongqian; Soh, Tingjin Sherryl; Chan, Kitti Wing Ki; Fung, Sarah Suet Yin; Swaminathan, Kunchithapadam; Lim, Siew Pheng; Shi, Pei-Yong; Huber, Thomas; Lescar, Julien; Luo, Dahai; Vasudevan, Subhash G.
2014Functional interplay among the flavivirus NS3 protease, helicase, and cofactorsLi, Kuohan; Phoo, Wint Wint; Luo, Dahai
2014High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5Liu, Chuan-Fa; Zheng, Jie; Yong, Hui Yee; Panutdaporn, Nantika; Tang, Kai; Luo, Dahai
2020Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 proteaseQuek, Jun Ping; Liu, Shuang; Zhang, Zhenzhen; Li, Yan; Ng, Elizabeth Yihui; Loh, Ying Ru; Hung, Alvin W.; Luo, Dahai; Kang, CongBao
2021Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3)Li, Kuohan; Zheng, Jie; Wirawan, Melissa; Trinh, Nguyen Mai; Fedorova, Olga; Griffin, Patrick R.; Pyle, Anna M.; Luo, Dahai
2021Interdomain flexibility of Chikungunya virus nsP2 helicase-protease differentially influences viral RNA replication and infectivityLaw, Yee-Song; Wang, Sainan; Tan, Yaw Bia; Shih, Orion; Utt, Age; Goh, Wei Yang; Lian, Bing-Jun; Chen, Ming Wei; Jeng, U-Ser; Merits, Andres; Luo, Dahai
2018Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturationVasudevan, Subhash G.; Peng, Minhua; Swarbrick, Crystall Marie Dawn; Chan, Kitti Wing-Ki; Luo, Dahai; Zhang, Wei; Lai, Xiaoping; Li, Geng
2017Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furinPeng, Minhua; Watanabe, Satoru; Chan, Kitti Wing Ki; He, Qiuyan; Zhao, Ya; Zhang, Zhongde; Lai, Xiaoping; Luo, Dahai; Vasudevan, Subhash G.; Li, Geng
2015Molecular basis for specific viral RNA recognition and 2' -O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)Zhao, Yongqian; Soh, Tingjin Sherryl; Lim, Siew Pheng; Chung, Ka Yan; Swaminathan, Kunchithapadam; Vasudevan, Subhash G.; Shi, Pei-Yong; Lescar, Julien; Luo, Dahai
2021Molecular insights into the flavivirus replication complexVan den Elsen, Kaïn; Quek, Jun-Ping; Luo, Dahai