NRF-CRP27-2021-0002

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Project title
NRF-CRP27-2021-0002

Publications
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Results 1-10 of 10 (Search time: 0.017 seconds).

Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa₃ supercomplex and a novel inhibitor targeting subunit cytochrome cI   [2023]

Mathiyazakan, Vikneswaran; Wong, Chui Fann; Harikishore, Amaravadhi; Pethe, Kevin; Grüber, Gerhard

Cryo-EM reveals transition states of the Acinetobacter baumannii F1-ATPase rotary subunits γ and ε, unveiling novel compound targets   [2024]

Le, Khoa Cong Minh; Wong, Chui Fann; Müller, Volker; Grüber, Gerhard

Cryo-EM structure of the Mycobacterium abscessus F1-ATPase   [2023]

Wong, Chui Fann; Leow, Chen Yen; Grüber, Gerhard

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with Clofazimine, Telacebec, ND-011992 or TBAJ-876   [2023]

Ragunathan, Priya; Ng, Pearly Shuyi; Singh, Samsher; Poh, Wee Han; Litty, Dennis; Kalia, Nitin Pal; Larsson, Simon; Harikishore, Amaravadhi; Rice, Scott A.; Ingham, Philip William; Müller, Volker; Moraski, Garrett; Miller, Marvin J.; Dick, Thomas; Pethe, Kevin; Grüber, Gerhard

High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo   [2024]

Ragunathan, Priya; Sae-Lao, Patcharaporn; Hamela, Claire; Alcaraz, Matthéo; Krah, Alexander; Poh, Wee Han; Pee, Carmen Jia Ern; Lim, Albert Yick Hou; Rice, Scott A.; Pethe, Kevin; Bond, Peter J.; Dick, Thomas; Kremer, Laurent; Bates, Roderick Wayland; Grüber, Gerhard

Inhibiting respiration as a novel antibiotic strategy   [2023]

Lee, Bei Shi; Singh, Samsher; Pethe, Kevin

M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments   [2023]

Kalia, Nitin Pal; Singh, Samsher; Hards, Kiel; Cheung, Chen-Yi; Sviriaeva, Ekaterina; Banaei-Esfahani, Amir; Aebersold, Ruedi; Berney, Michael; Cook, Gregory M.; Pethe, Kevin

Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery   [2023]

Harikishore, Amaravadhi; Mathiyazakan, Vikneswaran; Pethe, Kevin; Grüber, Gerhard

Synthesis of dihydrogambirtannine by alkyne [2 + 2 + 2]-cyclotrimerisation   [2025]

Seankongsuk, Pattarakiat; Sae-Lao, Patcharaporn; He, Shi; Pereira, Veronica; Bates, Roderick W.

Variations of the Mycobacterium abscessus F-ATP synthase subunit a-c interface alter binding and potency of the anti-TB drug bedaquiline   [2023]

Krah, Alexander; Ragunathan, Priya; Bond, Peter J.; Grüber, Gerhard